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R&D Specialist, Immuno Oncology -T Cell Biology

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, NY
Start date
Oct 24, 2019

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Job Details

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
We are seeking a self-motivated and ambitious individual to join the human anti-tumor T cell biology team in Oncology Research at Regeneron in Tarrytown, NY. The successful candidate will have a Masters degree in immunology or a related field as well as 3+ years of hands-on experience, and will work on a team that performs functional T cell assays on primary human blood and tumor immune cells. The work will mainly support clinical immune monitoring of samples from patients who are receiving immune modulating cancer therapies.
Key experimental approaches include both direct ex vivo analysis as well as in vitro immune cell culture. The candidate will be responsible for developing and executing functional assays on clinical materials using high-parameter flow cytometry and single cell sequencing. Previous hands-on experience with functional T cell assays and read-outs (antigen re-exposure assays, ELISPOT, multimer staining, functional flow cytometry) is desired.
The position also involves multi-color flow cytometry and cell sorting for downstream analysis. Preference will be given to candidates with bioinformatic data analysis expertise.

Responsibilities:
  • Expertly perform primary human immune cell co-cultures
  • Perform antibody and multimer staining for multiparameter flow cytometry
  • Independently operate high-parameter flow cytometers and cell sorters
  • Perform high-throughput T cell screening to determine antigen-TCR pairing
  • Collaborate with other internal research and clinical teams to jointly develop and advance technology-forward methods to evaluate human anti-tumor T cell function.
  • Independently develop and execute primary human immune cell functional assays.
  • Independently design multicolor flow cytometry panels and perform analysis.
  • Independently perform primary cell sorting.

Requirements:
  • Minimum of 3 years of experience in T cell biology
  • MS or BSc in immunology or related discipline preferred
  • Minimum of 3 years of hands-on technical experience in tissue culture, with preference for primary cell culture experience
  • Strong written and oral communication skills
  • Experience working in cross-functional teams
  • Prior experience with cell sorting preferred.
  • Prior experience with high-throughput immunological screening and single cell sequencing including TCR sequencing is preferred.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Company info
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States

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