Senior Scientist, Vivarium

Employer
AveXis Inc.
Location
San Diego, CA, US
Posted
Oct 20, 2019
Ref
2019-4231
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
Overview

Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science, starting with our proprietary gene therapy for the treatment of spinal muscular atrophy (SMA). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.

AveXis, a Novartis company, is dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product is a proprietary gene therapy approved by the US Food and Drug Administration for the treatment of pediatric patients with SMA. In addition to developing a treatment for SMA, AveXis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a genetic form of amyotrophic lateral sclerosis caused by mutations in the superoxide dismutase 1 (SOD1) gene.

The In Vivo Biology position in Research and Early Development will be responsible for the design, coordination, and execution of in vivo studies in support of pipeline development.

Responsibilities

  • Work interactively with research and development team to identify, validate, characterize, and distribute mouse models that directly address drug discovery and program validation.
  • Organize, schedule, and execute in vivo study plans designed in conjunction with scientific and program leads.
  • Performs tasks necessary for the husbandry and study of rodent models of disease such as animal identification, breeding, weaning, and collection of tissue samples.
  • Establish protocols for behavioral studies, execute behavioral testing, and successfully transfer assays to other team members.
  • Conduct molecular biology techniques necessary for genotyping.
  • Examine data and prepare technical reports, summaries, protocols and quantitative analysis, ensuring experiments are well documented and comply with regulatory requirements.
  • Maintain and ensure safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols.
  • Author, submit and revise Animal Care and Use Protocols (ACUPs).
  • Design, execute, and manage studies at external Contract Research Organizations (CROs).
  • Work collaboratively across a dynamic scientific environment.


Qualifications

  • PhD in a field related to biomedical research, neuroscience, or animal sciences or equivalent experience plus 5 years' relevant experience.
  • Good working knowledge of regulatory requirements required for in vivo research to remain compliant with IACUC and AALAC regulations.
  • Demonstrated ability to work collaboratively in a cross functional environment. Strong interpersonal skills.
  • Must have excellent troubleshooting, organization, and planning skills, and the ability to work under timelines in a fast-paced environment.
  • Experience with behavioral testing and characterizing rodent models of human disease is preferred.
  • Previous industry experience is preferred but not required.
  • Excellent oral and written communication skills.
  • Up to 25% travel may be required.


The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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