Research Scientist, Gene Engineering

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Description

The Transgenic Group is seeking a talented molecular and cell biologist to develop and characterize internal genetically modified animals (GMAs). The successful candidate will employ cutting edge technology to carry out both stem cell and embryo engineering to achieve gene targeting and gene editing. GMAs will support drug discovery, therapeutic programs, and in vivo studies.

Key Responsibilities

Culture and maintain embryonic stem cells and iPS cells.

Carry out ES cell engineering process under limited instruction.

ES cell screening, mouse screening and transgene expression/functional validation.

Mouse Breeding management.

Collaborate within and beyond transgenic department to further validate, characterize, and distribute mouse models.

Manage projects independently and present results in various settings.

Qualifications

Ph.D., MS with 3+ years, or BS with 5+ years in Biological Science field with relevant industry experience.

Mammalian cell engineering experience is required. Embryonic stem cell /iPS cell culture and manipulations are preferred.

PCR, RT-PCR, qPCR, gel electrophoresis and other routine molecular biology lab techniques are required. ddPCR and gene expression experience are preferred.

Direct experience with CRISPR gene editing techniques, gene transfer, and homologous recombination or HDR.

Strong understanding of mouse genetics and genotyping, mouse breeding and production, and downstream phenotypic analysis.

Capable of multi-tasking.

Excellent time management and organizational skills.

Excellent written and oral skills are necessary.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.