Scientist I, Chemist

Frederick, MD, USA
Oct 19, 2019
Required Education
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

  • Provide chemistry support to the FNL/NCI RAS Initiative and work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural biologists, and cell biologists to develop and optimize pharmaceutical agents for use as RAS inhibitors
  • Design and synthesize pharmaceutically relevant small molecules for targets implicated in cancer
  • Synthesis of covalent fragments to supplement our fragment screening library
  • Conduct hit-to-lead chemistry efforts around targets identified as advanceable hits
  • Stay informed of the latest findings in cancer drug discover and organic synthesis

  • Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
  • No experience is required beyond the doctorate degree
  • Strong background in organic synthesis and/or medicinal chemistry
  • Expertise in the design, synthesis, and characterization of pharmaceutically relevant small molecules
  • Familiarity with modern analytical technologies including: LCMS, NMR (1H, 13C, 2D techniques), HPLC, Flash chromatography, IR spectroscopy
  • Must be able to obtain and maintain a security clearance

  • 2 years of experience (post-PhD) in medicinal chemistry
  • Highly collaborative, self-motivated, and team-oriented
  • Experience of fragment-based drug discovery
  • Knowledge of cancer drug discovery
  • Familiarity with common screening platforms used in cancer drug discovery
  • Ability to balance workload over multiple projects
  • Excellent communication skills
  • Works well within a multidisciplinary team of Chemists, Biologists, and Computational Chemists

  • Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)