Scientist I, Chemist
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Oct 19, 2019
View more
- Discipline
- Science/R&D, Biotechnology, Chemistry
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
KEY ROLES/RESPONSIBILITIES
- Provide chemistry support to the FNL/NCI RAS Initiative and work closely with a highly collaborative multidisciplinary team of chemists, biochemists, structural biologists, and cell biologists to develop and optimize pharmaceutical agents for use as RAS inhibitors
- Design and synthesize pharmaceutically relevant small molecules for targets implicated in cancer
- Synthesis of covalent fragments to supplement our fragment screening library
- Conduct hit-to-lead chemistry efforts around targets identified as advanceable hits
- Stay informed of the latest findings in cancer drug discover and organic synthesis
BASIC QUALIFICATIONS
- Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
- No experience is required beyond the doctorate degree
- Strong background in organic synthesis and/or medicinal chemistry
- Expertise in the design, synthesis, and characterization of pharmaceutically relevant small molecules
- Familiarity with modern analytical technologies including: LCMS, NMR (1H, 13C, 2D techniques), HPLC, Flash chromatography, IR spectroscopy
- Must be able to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
- 2 years of experience (post-PhD) in medicinal chemistry
- Highly collaborative, self-motivated, and team-oriented
- Experience of fragment-based drug discovery
- Knowledge of cancer drug discovery
- Familiarity with common screening platforms used in cancer drug discovery
- Ability to balance workload over multiple projects
- Excellent communication skills
- Works well within a multidisciplinary team of Chemists, Biologists, and Computational Chemists
JOB HAZARDS OR REQUIREMENTS
- Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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