Clinical Biomarker Lead, Immuno-Oncology

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie in Redwood City, CA location.

We are searching for a Clinical Biomarker Lead in Immuno-oncology. In this role, you will report directly to the Director, Immuno-Oncology Clinical Biomarkers in Oncology Early Development and will join an experienced team to lead biomarker efforts for Abbvie sponsored clinical trials. To be successful in this role, the ideal candidate will have experience in the development and execution of biomarker strategies in cancer and/or immunotherapy trials.

KEY GOALS INCLUDE:

• Lead biomarker strategies for one or more clinical trials and serve as point of contact for all aspects of clinical biomarker strategy providing scientific expertise and leadership to programs
• Partner with clinical and discovery groups to create high quality biomarker strategies in the clinic
• Implement standardized and cutting edge tools to characterize drug mechanisms, potential diagnostic strategies, and for back translation research
• Leadership of biomarker subteams to enable cross functional collaboration on biomarker implementation
• Author biomarker sections of protocols, ICFs, IRB responses, regulatory documents, and others
• Pro-actively consult primary scientific literation, keep current on state of art technologies and emerging concepts in immuno-oncology

Basic:

• PhD, MD or PhD/MD degree in life sciences (oncology, immunology, pathology, molecular biology, cell biology or related field) and 6+ years industry experience of biomarker research in a clinical setting, preferably related to immunology or cancer biology

Preferred:

• Strong scientific background in tumor biology and immuno-oncology supported by publication record in these areas
• Clinical development experience interacting with teams conducting clinical trials
• Demonstrated leadership in translational sciences, employing pharmacodynamic, predictive and exploratory biomarkers
• Experience in analysis of large datasets and knowledge of biostatistics
• Experience in assay development, qualification and implementing biomarker assays on diverse platforms including IHC/IF, gene expression profiling, flow cytometry
• Companion diagnostics development experience is a plus
• Effectively work in a cross-functional team environment, interacting with various levels within the organization as well as vendors/academic sites/KOLs
• Organization, orientation to details, and effective time management with an ability to adapt to changing priorities
• Excellent written and oral presentation skills in the English language