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Principal Scientist, Immuno-Oncology Translational Bioinformatics

Employer
Bristol Myers Squibb Company
Location
Princeton, NJ, United States
Start date
Oct 17, 2019

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Job Details

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

We are seeking experienced computational scientists to join our Immuno-Oncology Translational Bioinformatics group. This group of computational scientists is responsible for advancing Bristol-Myers Squibb's industry-leading Immuno-Oncology pipeline through the strategic application of cutting-edge bioinformatics approaches. The scientists in this group analyze real-world health data, design experiments and analyze both pre-clinical and clinical-omics data sets, including RNA-Seq, Exome and Whole Genome Sequencing, single-cell sequencing, high-throughput proteomics, and multiplex flow cytometry in order to nominate novel drug targets, enable patient enrichment strategies, and guide drug development decisions. The group interacts with and influences all aspects of R&D at BMS, from early discovery through late-stage development as a key part of our Translational Medicine group.

Responsibilities
  • Engage clinical development team, biomarker scientists, biostatisticians and others key stakeholders to develop and execute biomarker data analysis strategies for oncology clinical studies
  • Perform analysis of clinical and biomarker datasets (e.g., large-scale omics datasets includingRNASeq, exome and whole genome sequencing, single cell sequencing) and derive clinically meaningful interpretations
  • Identify potential biomarkers for patient enrichment strategies and gain mechanistic insights of responses and resistances to I-O treatments
  • Summarize analysis results and report conclusions to BMS decision-making bodies; help communicate conclusions to regulatory agencies and the broad scientific community
  • Evaluate and adapt latest scientific findings and methods into bioinformatics analysis plans
  • Serve as a subject-matter expert and provide bioinformatics guidance in cross functional teams
  • Manage alliances and external collaborations


Qualifications:
  • Ph.D. in bioinformatics, statistics, biological or physical science with10+ years of industry experience
  • Demonstrated experience working with clinical study data is required; familiar with late stage clinical development process
  • Deep understanding of disease biology in immune-oncology is a strong plus
  • Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects while conforming with rigorous requirements of clinical studies
  • Broad experience with data generated by one or more high-throughput molecular assays: next-generation sequencing, flow cytometry, mass spectrometry proteomics, etc.
  • Strong experience using high-level programming languages such as R, MATLAB, Python or Perl for complex data analysis and reproducible research practices
  • Strong problem-solving and collaboration skills, as well as rigorous and creative thinking
  • Excellent communication, data presentation and visualization skills
  • Capable of establishing strong working relationships across the organization
  • Strong publication record


** This role can be based in either our Princeton, NJ, Cambridge, MA, or Redwood City, CA offices.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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Company info
Website
Phone
+1-800-332-2056
Location
430 E. 29th St
14th Floor
New York
New York
10016
United States

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