Senior Director of Allogenic CAR-T

Employer
Kite Pharma
Location
Santa Monica, CA, United States
Posted
Oct 16, 2019
Ref
R0010190
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
We are seeking a highly motivated and accomplished scientist to join Kite Pharma's Cell Therapy Research organization to lead the Allogeneic Cell Therapy Group. This challenging and important role will direct the team and drive the development of strategies to optimize the next generation of allogeneic cell therapy products.

RESPONSIBILITIES WILL INCLUDE

This role will manage the development and execution of design experiments, work with the sub-teams and their direct reports to execute program workflows, organize and analyze results, determine appropriate follow-up experiments and communicate program progress to the general research group and management. The role will manage program progress according to established timelines and adjust research focus as necessary to ensure progress is on-track.

The Sr Director will lead a team of scientists and associates focused on the development of normal donor and stem cell-based allogeneic product for engineered cellular immunotherapies. Responsibilities will include identifying and evaluating new approaches to allogeneic CAR-T engineering and assessing and their impact on T-cell development, phenotype, and potency of modified cell product, allogeneic responses, graft rejection and product persistence. This includes interfacing with the Product Sciences department to develop various T-cell methodologies towards initial clinical testing and into a commercial processes.

EXPERIENCE & QUALIFICATIONS
  • PhD degree in cellular biology, immunology, or a closely related field
  • 5+ years of industry experience
  • Direct experience/expertise in cellular immunology with focus on either transplantation or NK cell biology.
  • Experience in cell engineering using viral or non-viral methods and nuclease engineering with the goal of gene-therapy
  • Experience managing, mentoring and engaging direct reports
  • Expertise in multicolor flow cytometry, preferably in T-cell development and mature T-cell phenotyping
  • Expertise in automation systems, such as automated liquid handling robotics and bioreactors
  • A deep understanding of the mechanisms of immunological rejection of allogeneic cell therapies or transplant tolerance.
  • A demonstrated track record in drug discovery and development
  • A demonstrated ability to lead cross functional discovery programs.
  • Experience running programs and projects in an organized fashion and able to communicate status broadly, accurately and efficiently
  • Experience with T-cell product generation, preferably CAR-based or TCR-engineered T-cells
  • Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment
  • Comfortable in a fast-paced research environment with minimal direction, and able to adjust workload based upon changing priorities


Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability,genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contactcareers@gilead.comfor assistance.

For more information about equal employment opportunity protections, please view the'EEO is the Law'poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.