Scientist, Protein Expression Sciences

Location
Tarrytown, NY
Posted
Oct 13, 2019
Ref
17547BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
Protein Expression Sciences (PES) seeks an innovative PhD Scientist to develop new technologies to support Regeneron's antibody discovery pipeline. The technology development group is expanding efforts to develop high throughput methods and assays to better isolate and characterize antibody-derived fragments. This candidate would develop novel scaffolds for antibody expression, and advance new antibody isolation platforms and screening assays.
Responsibilities:

• Design and implement new methodologies to isolate antibodies from VelocImmune™ mice.

• Design alternative antibody scaffolds and reformat variable regions.

• Apply in-silico structure analysis to develop new antibody formats.

• Develop mammalian cell-based platforms to screen for antibodies with unique binding abilities.

• Collaborate with internal groups to develop high throughput assays to characterize antibody fragments for stability, affinity and antigen binding.

• Actively communicate results and prepare presentations for departmental meetings.
Requirements:

• PhD in Biochemistry, Cell Biology, Immunology, Molecular Biology or related fields.

• 3-5 years post-doctoral experience in antibody and/or protein engineering and expression.

• Experience with library construction, and high throughput screening.

• Expertise in one or more commonly used molecular modeling software packages, preferred.

• Strong molecular biology skills and tissue culture experience.

• Ability to work both independently and collaboratively in a team environment.

• Excellent communication and presentation skills.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.