Scientist I - Structural Biology
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Oct 12, 2019
View more
- Discipline
- Science/R&D, Biology, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
KEY ROLES/RESPONSIBILITIES
The candidate will join the structural biology group within the RAS initiative and will be responsible for the crystallization and the structure determination of protein-small molecule complexes by x-ray crystallography. The work will include construct design, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination, and analysis.
- The candidate will work closely with protein scientists, biophysicists, and protein NMR scientists as part of an integrated structural biology effort.
- The candidate will be a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization.
- The candidate will be expected to be able to participate in experimental design and to conduct experiments in a priority-driven environment independently.
- The candidate will be responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing.
- Work requires the use of personal protective equipment and adherence to strict safety protocols.
BASIC QUALIFICATIONS
- Possession of a Ph.D. degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline from an accredited college or university, according to the Council for Higher Education Accreditation. Foreign degrees must be evaluated for U.S. equivalency
- Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis
- Experience in the crystallization of protein-small molecule and protein-protein complexes
- Expertise in commonly used crystallography software packages
- Proficiency in protein biochemical and biophysical assays
- Excellent communication and witting skills
- Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data
- Must be able to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
- Experience in analyzing protein small-molecule interaction using isothermal titration calorimetry (ITC), differential scanning fluorimetry (DSF), and NMR techniques.
- Knowledge of mechanistic enzymology, structural biology, and protein chemistry
JOB HAZARDS OR REQUIREMENTS
- Candidate would be working with radioactive materials and requires them to become an approved radiation worker
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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