Senior Scientist, DMPK

South San Francisco, CA
Oct 11, 2019
Required Education
Position Type
Full time

As a Senior Scientist in the DMPK department, the successful candidate will lead the strategic direction of DMPK efforts on drug discovery and development project teams, working closely with colleagues from other disciplines to design, optimize, and develop locally targeted molecules.

Duties and Responsibilities

The Drug Metabolism and Pharmacokinetics (DMPK) department at Theravance BioPharma is seeking an experienced Ph.D. level Senior Scientist to support small molecule drug discovery and development programs. Primary responsibilities will be functional lead representation on Theravance Biopharma drug discovery and development project teams where the successful applicant will be required to influence the strategic direction of projects across the entire portfolio.  The candidate will be responsible for in vitro, in vivo and modeling/simulation resources and managing their flexible deployment to support project strategy. This will include the strategic use of CROs to supplement in-house resources as necessary. The candidate will design study protocols, conduct studies, review data and assess need for additional experiments/analysis; author and finalize reports in support of IND submissions. The successful candidate will work closely with colleagues from Biology, Chemistry, Translational Sciences to design impactful preclinical studies with clinical translation in mind.

The successful candidate will exhibit an energetic and innovative approach to problem solving. Strong communication/interpersonal skills with a desire to work in a fast-paced, flexible and dynamic environment is required.


  • PhD in Pharmaceutical Science, Pharmacokinetics, Biochemistry, Chemistry or a related Life Science
  • Strong experience leading DMPK discovery and development strategy and working in cross-functional team environments
  • 5+ years of progressive industry (pharma, biotech, etc) experience in DMPK
  • Familiarity with IND-enabling studies and clinical drug development
  • Familiarity with localized drug delivery (e.g., GI tract, lung, ocular, dermal) is preferred
  • Excellent written and verbal communication skills

Direct Reports

No immediate direct reports but the successful applicant will be anticipated to manage in a matrix-based environment.

Physical Requirements

The incumbent may be required to sit, stand and walk for extended periods of time.  The incumbent may be required to climb, bend, lift, carry and kneel.  Because of the volume of work performed by computer and telephone, the incumbent will spend a considerable amount of time looking at the computer monitors and using his/her hands to operate office equipment.

Working Conditions

Being present and productive within normal working hours.