Research Scientist, Bioinformatics

Employer
Kite Pharma
Location
Gaithersburg, MD, United States
Posted
Oct 09, 2019
Ref
R0010209
Required Education
Doctorate/PHD/MD
Position Type
Full time
Everyone at Kite is grounded by one common goal - curing cancer. Every single day, we seek to establish a direct line between that purpose and our day-to-day work. Join us in our mission!

We are seeking a self-motivated and ambitious individual with strong work ethic to join our personalized neoantigen TCR development research program as a Research Scientist in Bioinformatics at our new research and clinical production facility in Gaithersburg, Maryland. The facility is being developed as a Center of Excellence for the advancement of novel TCR mediated T cell therapies targeting tumor mutations and antigens.

Reporting to the Principal Scientist in Bioinformatics, the individual will contribute to the development and implementation of state-of-the art bioinformatics platforms for TCR discovery and neoantigen identification. A deep understanding of the current experimental methodologies used in single-cell TCR and transcriptome sequencing, and DNA/RNA NGS sequencing is required. Demonstrated ability to synthesize scientific questions into a coherent research effort and communicate scientific findings cross-functionally is required.

Responsibilities include, but are not limited to:
  • Spearhead the establishment, analysis and evolution of single-cell TCR and transcriptome data analysis
  • Contribute to the analysis and interpretation of DNA/RNA NGS sequencing data with a focus on neoantigen identification
  • Supply to the development of prediction algorithms to identify neoantigens with highest therapeutic relevance
  • Build analytical workflows for automated and integrated deployment of bioinformatics tools in a high-performance computing environment for evaluation of all NGS data, in particular single-cell TCR and transcriptome data
  • Contribute to the analysis and interpretation of large data sets, including mining of immunological datasets for e.g. biomarkers, therapeutic targets, cancer mutations
  • Participate in a cross-functional team responsible for the company-wide scale-out of bioinformatics infrastructure as well as external scientific discussions on technology evaluation
  • Work closely with research and cross-functional teams to jointly advance the development of neoantigen and TCR discovery platform


Requirements:
  • Ph.D. degree in Bioinformatics, Computational biology or a closely related field and 3+ years of post-doctoral academic or industry experience
  • Evidence of a successful academic or industry track-record is required
  • Hands-on experience with single-cell data sets and transcriptome analysis for TCR discovery is required, and experience in prediction algorithms to identify T cell epitopes and machine learning is highly desired
  • Hands-on experience applying computational tools to study cancer mutations and T cell immunity, in particular experience in Illumina sequencing data and NGS pipelines, analysis of cancer genomic data sets with a focus on identifying tumor mutations is required
  • Full proficiency in R and/or Python, experience in Linux environments and cloud computing systems and the development of statistical methods and algorithms
  • Excellent interpersonal, verbal and written communication skills are essential
  • Strong verbal and written communication, and analytical skills
  • Proactive, self-motivated and ambitious person with a strong work ethic, ability to work in a dynamic environment and able to adapt to changing priorities


Does this sound like you? If so, apply today!

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Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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