Director - Computational Biology

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.
The Clinical Biomarkers & Diagnostics department at Amgen is seeking a highly motivated Director of Computational Biology and will work out of our South San Francisco or Thousand Oaks research sites.
The Computational Biology group is responsible for biomarker data analysis for all Amgen's first-in-human studies in all therapeutic areas. In that capacity, we conduct the statistical analysis of clinical biomarker data to demonstrate the pharmacodynamic effects of our therapeutics and in the pursuit of biomarker discoveries that will aid in drug development and patient stratification.

Position Responsibilities
Work cross-functionally within Amgen and to interact closely with the clinical development groups
Focus on leading a team to develop and execute a biomarker data analysis strategy that informs biochemical coverage, pharmacodynamics, mechanism of action, and patient stratification/selection in support of the progression of Amgen's pipeline candidates from late preclinical development through all stages of clinical development
Direct and approve experimental designs, create and implement data analysis plans, interpret and communicate results as written reports and verbally to cross-functional teams
The core computational function of the group requires that we leverage and manipulate highly complex internal and external datasets, and we expect the candidate to have a deep understanding of cutting edge tools in statistics, machine learning and AI
A deep knowledge of assay qualification and IVD development is an important aspect of the group and the role, as the team interfaces closely with assay laboratories and the In-vitro Diagnostics group in the development of biomarker assays, companion and complementary diagnostics

Basic Qualifications
Doctorate degree and 4 years of scientific experience
OR
Master's degree and 7 years of scientific experience
OR
Bachelor's degree and 9 years of scientific experience

Preferred Qualifications
Advanced degree in Bioinformatics, Biostatistics, Computer Science, Genomics
Experience in analyzing clinical biomarker data
Knowledge and experience in clinical trial design
Experience in companion diagnostics development and knowledge of regulatory submission requirements of in vitro diagnostic devices in multiple markets
5+ years of experience in pharmaceutical industry
Hands-on experience in the fields of bioinformatics and genomics including working with various public and proprietary data repositories (e.g., TCGA, GTEx, dbGaP, Ensembl, UCSC genome browser, Array Studio), bioinformatics tools (e.g., BLAST, GATK, Cell Ranger, samtools, VEP), and statistical environments (e.g., R, S+, Matlab)
Experience with manipulation, interpretation, and innovative analysis (e.g. novel algorithm development) of large biological datasets, including single-cell sequencing data
Proficient in programming (e.g., Python, Java, C/C++) and working in a Unix/Linux environment; ability to develop customized bioinformatics tools
Experience integrating data from multiple sources and identifying critical process variables
Experience establishing and reviewing complex plans for multiple projects or activities. This includes planning resource allocation and distribution and identifying contingency plans

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development Ways that you will display your leadership acumen in this role include:

• Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
• Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
• Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
• Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
• Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
• Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans
• Assisting staff with preparing for roles of growing responsibility and identifying new opportunities that expand their skills and align with their overall career objectives
• Resolving critical gaps in the organization's internal capabilities and skillsets, including strategic external recruiting
• Identifying diverse, qualified successors for key positions
• Ensuring that direct reports who also lead people consistently demonstrate these same behaviors with their staff

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.