Senior Research Investigator (IO Resistance Biology)

Cambridge, MA, United States
Oct 07, 2019
Required Education
Position Type
Full time
Senior Research Investigator (IO Resistance Biology)

Bristol-Myers Squibb R&D is a science-driven, passionate organization determined to discover, develop and deliver medicines that have the potential to transform the lives of patients and establish new standards of care in areas of high unmet need. Patients' needs and scientific discovery are our driving force. The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will position our scientific team in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. Our scientists will focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology therapies. These are significant challenges that will require innovative solutions from the biopharma, biotech and academic communities.

Roles and Responsibilities

We are seeking a Senior Research Investigator, who will be responsible for evaluating mechanisms of resistance to IO therapy in the patient setting. Experienced candidates will have have working knowledge of the refractory IO landscape and have been exposed to the theories and implications of the newly evolving field of acquired resistance. The Senior Research Investigator, will identify and evaluate molecular and cellular signatures that can be explored to tease out the mechanistic underpinnings as to why some patients fail IO therapy. A broad working knowledge of genomics, proteomics, preclinical modeling and cellular biology with exposure to various technology enabling platforms, addressing questions in the clinical context is required. The candidate will be expected to partner closely with our bioinformatics, pathology and "omics" teams onsite and will participate in internal and external scientific meetings, presenting their data and critically evaluating emerging scientific literature and technologies to contribute to the projects they are assigned to. We are seeking a self-motivated, proactive contributor for a dynamic, fast-paced multidisciplinary team.

Qualifications / Essential Skills

MD/PhD or PhD in cancer biology, or equivalent advanced relevant biology degree

Experienced scientist with 3-5 years' of post-graduate research experience, with a minimum of 2 years post-doctoral studies in a clinical or translational setting

Candidate will have in-depth knowledge / understanding of the cancer therapeutic landscape utilizing NGS platforms to tease out mechanistic insights with respect to response and resistance to a given therapeutic regimen

Participated in clinical studies to better characterize the molecular underpinnings of therapeutic resistance in patient cohorts and correlation with clinical outcome

A track record of independent critical thinking and scientific achievement demonstrated by first authorship in recent high impact publications

Exposure to cancer immunotherapy including immune-checkpoint blockade with knowledge of current therapeutic landscape is highly desirable

Recent experience in supervising bench scientists in an academic or industry setting is desirable

Experience in balanced experimental design, data visualization and working knowledge of NGS pipelines and statistical analysis tools are desirable

Excellent interpersonal skills and ability to communicate, both written and oral effectively and efficiently within the BMS organization and with external partners/collaborators

Thrives in fast-paced, dynamic work environment, bringing a pro-active mentality to the role

We follow the science and we'll continue to invest in translational medicine research, deepen our understanding of disease biology and uncover insights about predictive biomarkers with the ultimate goal of making precision medicine a reality for more patients.