Bristol-Myers Squibb Company

Senior Research Investigator I - NGS

Location
Redwood City, CA, United States
Posted
Oct 07, 2019
Ref
R1516545
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

We are looking for an experienced PhD-level Senior Research Scientist to lead the Next Generation Sequencing (NGS) operations within the antibody generation group. NGS is an integral part of our ongoing efforts to discover novel therapeutic antibodies. This scientist is expected to lead a team and directly contribute in every aspect of NGS operations from high throughput sample and library preparations, NGS data analysis (Deconvolution, Sequence level QC and Defining Antibody Variable region domains) and mining large Antibody sequence datasets.

Major Responsibilities
  • Apply molecular biology approaches such as RT-PCR to recover transcripts of interest, in high throughput automated environment.
  • Follow current NGS protocols, prepare cDNA samples and help run NGS machines as necessary.
  • Upload, QC and Analyze NGS data and communicate results to appropriate stakeholders.
  • Identify gaps where data analytics and/or visualization will help us understand and share our data and results.
  • Collaborate with IT business partner to refine and implement solutions including coding as necessary where "off the shelf" solutions are not available.
  • Manage a team of PhD and non-PhD level scientists.
  • Excellent written and oral skills are necessary.
  • Accomplish goals under project team time lines.


Qualifications
  • PhD with 4 years' industry experience. The degree should be in molecular biology or related field.
  • Demonstrated experience in molecular biology techniques especially RT-PCR and PCR is required.
  • Direct Experience with Antibody sequence analysis including germline and domain definitions is required.
  • Coding/Scripting experience
  • Ability to handle large number of delicate samples simultaneously is required.
  • Past experience with automation is desirable.
  • Past working experience with Illumina MiSeq is required,
  • Experience with 10X genomics or other NGS platforms is desirable.
  • Good work ethics and being self-motivated is essential.
  • Excellent communication and time management skills are required.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.