R&D Associate, Histotechnologist

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

The successful candidate will work in close collaboration with the lead microcopy scientist to develop, optimize, automate, and execute new histology, immunohistochemistry and in situ hybridization protocols for preclinical rodent model studies throughout all therapeutic focus areas of Research. Together with the lead microscopy scientist, this role will also coordinate histotechnological protocols, instrumentation, techniques, and reagents throughout Research, including training and support of scientific personnel. Regeneron's broad and ever evolving preclinical research portfolio will require the candidate to be independent, organized, and able to coordinate work flow and deliverables with the internal and extended teams, all while maintaining a high standard of quality.

Current and emerging projects include: optimization of IHC/IF protocols to detect in vivo administration of Regeneron antibodies across a variety of tissue types, characterization of targets in lung fibrosis, detection and characterization of peripheral nerve enervation in various mouse models, and optimization of multiplexec IHC/ISH fluorescence protocols to support spectral unmixing imaging for immune cell profiling in tumor microenvironment. Projects are constantly evolving and will change as new ideas and opportunities present themselves.

Responsibilities:

• Working closely with the lead microscopy scientist to understand project needs and priorities, troubleshoot experiments, and provide updates on the progress of projects.

• Independent execution of projects planned in consultation with the lead microcopy scientist and other collaborating scientists.

• Development of histological techniques including antibody and probe validation, optimization across multiple tissue types, combined IHC/ISH protocols, quenching autofluorescence, multiplexed fluorescence RNAScope, and more

• Handling small animals including euthanasia followed by intracardial perfusion and dissection for tissue harvesting.

• Experimental animal tissue dissection, sample preparation, sectioning, staining, and histological analysis of multiple animal models.

• Testing, integration, and support of new robotics technologies and assays to streamline and automate histological protocols.

• Lab operations including organization of materials and reagents required for studies and maintainance of histology equipment to ensure high quality laboratory practices are followed.

• Maintain online and physical records of the data from ongoing and completed projects.

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Requirements:

8 years lab experience

The position requires a Bachelors degree in science having at least 8 years of relevant experience.

• Extensive experience in basic and advanced histological techniques such as cryo and paraffin sectioning, immunohistochemistry, immunofluorescence, and in situ hybridization, including RNAScope and multiplexed technologies. Experience with resin/plastic embedding and sectioning is a bonus.

• Experience with histological robotic equipment such as the Leica BOND Rx or Ventana Discovery Ultra, and with white light and fluorescence digital pathology slide scanners such as the Aperio AT2, Leica SCN400, Zeiss Axioscan, or similar.

• Substantial knowledge of vertebrate anatomy

• A proven history of executing and accomplishing projects in a timely and independent manner within a laboratory setting is required, pharmaceutical industry experience is preferred.

Additional requirements:

• Strong communication and interpersonal skills

• A passion for biology and helping others

• Attention to detail, and due diligence in execution of projects

• Ability to shift focus between multiple projects while still meeting deadlines

• A proven ability to work independently and collaboratively as part of a larger project

• A dedication to share, collaborate, and lift up others

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.