Postdoctoral Research Fellow Development of Novel Mass Spectrometry Ionization Methods for Bioassay

Lake County, IL, US
Oct 04, 2019
Required Education
Position Type
Full time
AbbVie is a global, research-based biopharmaceutical company with a mission to use expertise of dedicated people and unique approach to innovation and to develop advanced therapies that address some of the world's most complex and serious diseases. The Postdoctoral Program is designed for true investigational and experimental research. Participants will be mentored by renowned industry scientists and collaborators at AbbVie and focused on delivering cutting-edge advancements in discovery, development new treatment modalities. The enriching training program offers a balance of structured learning and work experience which fosters a learning environment to advance individual development with accessibility to high-level knowledge building across the drug development continuum.

To be successful, we need outstanding individuals willing to challenge themselves to find the best solutions for our patients. The AbbVie Postdoctoral Program is one way we are doing just that.

Through our Postdoctoral Program, we are hiring postdocs from key academic institutions for preferred areas of science in the U.S., while providing a unique opportunity for participants to build a solid career foundation in the pharmaceutical industry while building the AbbVie brand as an employer of choice for scientific talent. Participants in the Postdoctoral Program play an integral part in our continued success and will help us to further grow as a leader in our industry. The successful candidate will conduct novel and impactful research over a 2-3-year period. High-impact publications and presentations at scientific meetings are expected outcomes along with the opportunity to gain valuable experience working within a top-tier biopharmaceutical company. This assignment is expected to be for two years minimally and no more than three years.

Drug Discovery addresses key unmet medical needs through the identification and validation of therapeutic targets, generation of leads, and optimization of those leads into drug candidates for clinical evaluation. Recently a novel ionization method for Mass Spectrometry was described with potential to directly assay analytes from biological samples with no sample preparation. As a member of the Protein and Assay Sciences group in the Drug Discovery Science and Technology (DDST) area, the Post-Doctoral Scientist will lead the development and implementation of cutting-edge direct analysis MS methods utilizing ambient ionization technologies in a drug discovery and development setting. The successful candidate will collaborate in a cross-functional team, across several groups in the R&D organization and have the opportunity to gain deep understanding and hands-on experience in lead discovery, biomarker discovery, in-vitro pharmacodynamic and target engagement assays.

Scientific Focus:

Development of this technology platform and its application to drug discovery is highly novel. The candidate will work in a highly multidisciplinary team to optimize the platform and apply novel analytical approaches to biological and chemical assays using advanced ion source technologies. Initially, the research will focus on direct analysis of compounds and/or cellular PD markers and biomarkers related to disease from cells, tissues, and biological samples. As the technology becomes established phenotypic and metabolomic studies employing machine learning for safety and efficacy translation will be explored. Based on the multiple applications to be explored and the potential high impact on our industry, we expect this work will result in numerous publications and presentations that describe both the technology and its application. This work will also be instrumental for AbbVie to internalize the technology as a first mover.

Key responsibilities include :
  • Design and perform proof of concept experiments to establish potential and limitations of ambient ionization for direct analysis using mass spectrometry
  • Participate in instrument design, engineering, and beta-testing
  • Expand MS application space within drug discovery to enable novel, previously impossible, biological experiments
  • Lead establishment of novel MS techniques as a platform assay technology for high impact areas
  • Publish/present project-related research in high-impact peer-reviewed journals and scientific meetings.

Desired Skills & Experience:
• PhD in Analytical Chemistry, cell biology, chemical biology, or biochemistry
• Hands on experience with mass spectrometry and biological assay development is required. Experience with cell culture and cellular assays, protein biochemistry and biochemical assay development is preferred.

Basic Qualifications:
• Successful completion and defense of a PhD in analytical chemistry, cell biology, chemical biology or biochemistry. Minimum graduate school GPA 3.0; 3.5 preferred. Graduate of accredited and nationally ranked university.
• Research background in mass spectroscopy and familiarity with MS vendor software
• Demonstrated proficiency with using sophisticated instrumentation and eagerness to learn and master new biology and chemistry skills
• Record of publication in a prestigious journal(s).
• Excellent problem-solving skills including critical and analytical thinking.
• Excellent communication, leadership, and project management skills.
• Demonstrated scientific writing skills and strong verbal communication skills.
• Demonstrated ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies.
• Proven track record of teamwork, adaptability, innovation, initiative, and integrity. Global mindset to thrive in a diverse culture and environment.
• Ability to multitask and work within timelines.
• Record of publication in a top-tier peer reviewed journal(s).
• Work authorization in the United States

Preferred Qualifications:
• Experience with cell culture and cellular assay development
• Basic protein biochemistry and biochemical assay development experience
• Knowledge of basic statistical concepts
• Provide three letters of recommendation from thesis advisor and thesis committee members

Key Leadership Competencies:
• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance
• Learns fast, grasps the "essence" and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook or LinkedIn. At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex, (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status or any other legally protected characteristic.