Scientist - Tumor Immunology

Employer
PACT Pharma
Location
South San Francisco, CA
Salary
base + bonus + benefits
Posted
Oct 03, 2019
Ref
2019081
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time

PACT Pharma is an exciting, well-funded clinical stage company. We are located in South San Francisco in the heart of the world’s premier biotechnology research hub.  PACT is developing personalized adoptive T cell therapies for the eradication of solid tumors.  PACT Pharma offers a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants. 

PACT is developing tumor-mutation targeted T cells tailored for each patient. Tumor mutation (neoE) targeting is programmed into the patient’s own T cells to seek out & kill the tumors. Using (non-viral) precision genome engineering, the neoE-targeted Tcell receptors (TCRs) replace the endogenous TCR of fresh CD8 and CD4 T cells collected from that same patient followed by minimal expansion in closed systems for re-infusion into the patient. These patient-specific neoTCR-P1 cells are formulated to immediately kill all neoantigen-expressing tumors, together with a deep reservoir of ‘ready-to-go’ neoTCR-P1 cells for long term persistence and capable of rapid expansion to prevent future cancer recurrence.

We are currently recruiting for Scientist in the Tumor Immunology group. The ideal candidate will be experienced in immunology and T cell biology. She/he will be responsible for the design and execution of critical path experiments for the development of the optimal neoE TCR T cells for adoptive cell therapy. This research will focus on supporting studies to identify the TCR requirements for optimal functional avidity and the T cell profile for the most favorable homing and longevity. Moreover, she/he will have the unique opportunity to interrogate a world-class database from the preclinical development and clinical trial with the goal of providing additional insights about our product and improving the personalized medicine field. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment.

Responsibilities:

  • The candidate should be highly proficient in state-of-the-art techniques for characterizing T cell biology.
  • She/he must demonstrate ability in rigorous design and careful implementation of cell-based and biochemical assays.
  • She/he must have experience analyzing genomic datasets such as RNA-seq, ChIP-seq, or ATAC-seq, to understand cellular gene regulatory networks.
  • She/he must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports.

Minimum Qualifications:

  • The ideal candidate will hold a PhD, with career focus in Immunology. Industry experience is a plus.
  • She/he will have a deep understanding of T-cell biology and T cell receptor binding affinities and kinetics.
  • She/he will have experience with cell-based immunological assays to assess T-cell function and to evaluate the peptide-MHC-TCR affinity, avidity and dissociation kinetic.
  • She/he will have experience with sequencing data analysis.
  • She/he should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.

Preferred Qualifications:

  • Experience with informatics, data management, and programming

PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.