Associate Scientist II/ Scientist I, Drug Product Development (Physicochemical Characterization)

Employer
AbbVie
Location
Worcester, MA, US
Posted
Sep 29, 2019
Ref
1905939
Required Education
Bachelors Degree
Position Type
Full time
The Drug Product Development team at the AbbVie Bioresearch Center in Worcester, MA is responsible for designing and developing formulations that enable delivery of AbbVie's candidate molecules in a dosage form suitable for preclinical or clinical studies. We are seeking a highly motivated, collaborative scientist with a proven track record in physicochemical characterization of small molecule candidates and application of drug delivery approaches in preclinical development.

Key Responsibilities Include:

  • Execution of studies to characterize the physicochemical properties of candidate molecules in preclinical development
  • Design and preparation of formulations, including solutions /suspensions/emulsions, to enable preclinical acute and chronic in vivo studies
  • Interpret and communicate results from characterization and formulation studies to advise the selection of molecules with properties suitable for development


Position will be hired based on level of experience.

  • BS or MS with typically 3-5+ (BS) or 0+ (MS) years of experience in Pharmaceutics, Pharmaceutical Sciences, or Chemistry.
Preferred:
  • Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
  • Working knowledge of physiological barriers to drug absorption, including various potential transport mechanisms.
  • Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
  • Experience with analytical approaches toward physicochemical characterization of pharmaceutical dosage forms (i.e. HPLC, UPLC, MS, DSC, TGA, PXRD, dissolution)
  • Experience with various milling techniques and particle size analysis
  • Understanding crystalline and amorphous materials and their impact on drug development
  • Excellent oral and written communication skills.
  • Demonstrated ability to work collaboratively in a cross functional team setting.


Key AbbVie Competencies:

  • Builds strong relationships with peers to facilitate communication and enable higher performance.
  • Learns fast, grasps the "essence" and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others and nurtures innovation