Associate Director,Genetic Epidemiology-CV, Metabolic, Musculoskeletal
- Employer
- Regeneron Pharmaceuticals, Inc.
- Location
- Tarrytown, NY
- Start date
- Sep 27, 2019
View more
- Discipline
- Science/R&D, Genetics
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
Summary:
We are looking for a talented Genetic Epidemiologist with strong quantitative skills to join our Cardiovascular, Metabolic and Musculoskeletal Therapeutic Area Genetics team. The post holder will have key responsibilities in mining large human genetics datasets including 100,000s of genotyped and sequenced participants, in partnership with other RGC teams, to translate genetic findings into new therapeutic insights.
The key goals of the post will be (a) to empower the translation of genetic association findings into new therapeutic targets, indications and precision medicine approaches that will enable Regeneron to deliver better medicines to the patients who need them in the fields of Cardiovascular, Metabolic and Musculoskeletal Medicine; (b) to support existing pre-clinical and clinical development programs within Regeneron in these Therapeutic Areas using human genetics approaches; (c) to form strong partnerships with the Analytical Genomics, Clinical Informatics, other RGC's teams to accomplish the goals of the Therapeutic Area Genetics team, RGC and Regeneron at large.
Responsibilities:
• Design and execute complex analyses across datasets to accomplish the translational goals of the Therapeutic Area Genetics team.
• Work in close collaboration with other Therapeutic Area Genetics team members and form a strong partnership with Analytical Genomics, Clinical Informatics and other RGC teams to deliver on complex, top-quality scientific endeavours in these Therapeutic Areas.
• Generate, summarise, and present results in internal and external meetings to a variety of audiences. Lead or contribute to the writing of scientific reports and publications.
• Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC and Regeneron.
• Collaborate with external industry and academic partners in scientific consortia.
Requirements:
• PhD in Genetic Epidemiology, Statistical Genetics (with an applied focus), Human Genetics or similar and strong quantitative and analytical skills.
• 5+ years of experience and/or an outstanding level of achievement in the field of large-scale human genetics post PhD.
• Expertise in the genome-wide and gene-centric analysis of large human genetics datasets for translational insights. The successful candidate will use (a) Mendelian randomization to elucidate causal mechanisms and evaluate whether pharmacological treatment of a target is likely to be effective and safe; (b) polygenic risk scores to enhance etiologic understanding and genetic prediction, (c) fine-mapping and other prioritization approaches to identify causal variants and genes underlying genetic association signals and (d) will routinely combine information across multiple traits, variants and data sources to generate new insights. An outstanding candidate will have contributed to the application of these methods to important biological problems in the field of Cardiovascular, Metabolic and Musculoskeletal Medicine.
• Expertise with modern cluster and cloud computing environments and with statistical analysis software (R environment for statistical computing, STATA) and human genetics analysis tools (METAL, GCTA, PLINK or similar).
• Interest in understanding the genetic basis of Cardiovascular, Metabolic and Musculoskeletal diseases and translating this knowledge into therapeutic insights. An outstanding candidate will have previously worked on cardiovascular, metabolic or musculoskeletal phenotypes.
• Ability to work in a highly interactive environment with a diverse team of colleagues. Ability to provide mentorship and guidance to more junior colleagues to help them develop their full potential and build new skills and abilities.
• Outstanding communication skills and an ability to summarize and present the results of human genetic studies to a variety of technical audiences, ranging from experts in statistical genetics, human genetics, biology, drug design and medicine.
• A commitment to high-quality science and to the highest standards of research and work ethics and integrity.
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Company
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
Stock Symbol: REGN
Stock Exchange: NASDAQ
- Website
- https://www.regeneron.com/
- Phone
- 914-847-7000
- Location
-
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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