Co-op - Bioinformatics, Spring & Summer 2020

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

This position is in Bioinformatics in Tarrytown, NY. There are 4 positions for Spring AND Summer (full time, about 7 months from January to August 2020). Each opening is described below.

Position 1:
The team is working on cutting-edge computation biology research problems in the immune-oncology space is looking for a student who is interested in machine learning and would like to play with multi-omics biological data (next generation sequencing data, mass-spectrometry data, etc.) The student will be involved in biological data analysis as well as data visualization. This position will provide a terrific opportunity to learn and apply skills in a variety of areas of computational biology to solve complex research problems.

Position 2:
The Tier1 process at Regeneron analyzes gene function using a standardized set of phenotyping assays to study the effects of targeted mouse gene knockouts. This process is an early part of R&D to identify potential biological drug targets. The Regeneron Bioinformatics Core Service manages the organization, analysis and presentation of Tier1 data generated with a variety of technologies, such as automated serum chemistry and hematology instruments, fluorescence activated cell sorting (FACS), microcomputed tomography (uCT) and high-resolution episcopic microscopy (HREM) and RNASeq. Regeneron has accumulated more than a decade's worth of Tier1 data for nearly 1000 genes.
The proposed project is to develop and implement a strategy for managing, integrating and analyzing heterogenous data from many sources. This work is intended to facilitate and participate in the development of new biological insights through data mining and meta-analysis

Position 3:
This co-op will work in prioritizing and integrating biological data. The Bioinformatics Core Service (BiCS) works to help many departments at Regeneron identify potential biological drug targets as an early step in the R&D process. BiCS manages the organization, analysis, and presentation of data generated by the Pre-therapeutic Target Discovery (PTTD) group via an array of technologies for evaluating the phenotypic effects of targeted mouse gene knockouts on gene function. BiCS has also developed internal tools to help increase the utility of the large quantities of variant genes identified within the Regeneron Genetics Center (RGC) Mendelian Project, associating these genes with diseases and their corresponding phenotypes, which may lead to the development of drug candidates. Regeneron has accumulated more than a decade's worth of Tier1 data for nearly 1000 genes, and an ever-growing repository of genotype and phenotype data within the RGC.
The proposed project is to leverage this data by (1) optimizing, modularizing, and making more readily accessible the existing tools for ranking variant genes as a function of OMIM-associated phenotype annotations and (2) building additional tools for integrating PTTD and RGC data in order to generate new biological insights. The intern will participate in these efforts with a project that entails database ETL activities (Extract Transform Load) from open source databases and internally generated data, and the further coordination of data across departments. There will be learning opportunities in integrative algorithm development, semantic similarity analysis, MySQL, R, API (application programming interface) construction, and Shiny as well as REGENERON technologies.

Position 4:
In the age of genome resequencing projects, there is a persistent need to engage in de novo assemblies of various mammalian and bacterial model organisms. Sometimes, the publiclly available reference genome may be significantly divergent from the organism of interest. In other cases, a particular region of therapeutic interest may not be well characterized or may be error-prone. In those cases, a de novo assembly approach with subsequent comparitive analysis to a known public reference or a familial cohort may elucidate new scientific avenues.

This co-op student will work with a mentor to research, design and implement a de novo genome assembly and analysis bioinformatics workflow that will run in a compute environment on the cloud. The de novo assembly workflow includes incorporating various next-generation sequencing platforms such as Illumina and Pacific Biosciences, as well as other information such as optical mapping data. Furthermore, the student will also investigate popular algorithms for assembling difficult genomic regions such as repeats and GC-rich areas. Finally, the student may also research and investigate algorithms that characterize variation across the genome such as is possible with CRISPR/Cas9 editing.

Start building your skills at Regeneron.

• Must be a 3rd year undergraduate or above

• Must be pursuing a degree in computational biology, bioinformatics, biostatistics, biomedical informatics, bioengineering, computer science, computer engineering or related field

• Must have experience with data analysis (experience with biological data is a big plus), machine learning, R, Shiny, Python

• Computing experience in Unix/Linux environment preferred

• Some background in life sciences would be helpful but is not required

General Co-op Program Information:

• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD

• Program is full-time (~40 hrs/wk) and is paid

• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community

• Minimum GPA of 3.0

• You will work with a specific manager on a project(s)

• Enjoy regular 1 hour Co-op Program events: learn about other areas of the company from employees, soft skills workshops, networking, volunteering, and more!

• Present to your team on your project(s)

Transportation and Housing:

• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus

• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.