Amgen

Associate Scientist, Bioanalytical

Employer
Amgen
Location
Cambridge, MA, US
Posted
Sep 24, 2019
Ref
R-83880
Required Education
Bachelors Degree
Position Type
Full time
Associate Scientist - AMA PKDM

Amgen is seeking a bio-analytical scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Cambridge site in Massachusetts.

In this role you will contribute to Amgen's discovery and development portfolio with a major focus on small molecule quantitative bio-analysis by LC/MS/MS. These bio-analytical supports are a critical component of all pharmacokinetic and pharmacodynamic investigations as well as in vitro assessments of the ADME properties of small molecule drug candidates and bio-markers placing this role at the center of Amgen's drug discovery engine.

In addition, this position will be involved in developing innovative assays to meet the needs of Amgen's multimodality discovery and development portfolio contributing to the mechanistic insights of distribution, clearance pathways and target engagement with an emphasis on Neuroscience and small molecule therapeutics. You will work directly with other PKDM stakeholders at other Amgen research sites to influence drug discovery direction through bio-analysis

In this position the core responsibilities are to:
  • Conduct PK and bio-marker bio-analyses of in vitro and in vivo samples for project teams with strong emphasis on quality, robustness and speed.
  • Develop, optimize and troubleshoot LC/MS/MS based assays. Analysis, interpretation, and communication of study results
  • Work closely with PKDM team members, effectively communicate with project team representatives and actively participate/collaborate cross site and cross functionally.
  • Provide expertise in LC/MS applied to bio-therapeutic and bio-marker analysis.
  • Implement new assays, techniques, improve processes and evaluate new technologies/instrumentation including automation procedures to improve efficiency


In addition to the core responsibilities, this role also allows the individual to write scientific reports, author scientific papers and present at scientific meetings where appropriate. A collaborative and highly capable scientific cross-site community at Amgen is available to support these efforts.

Basic Qualifications:

Master's degree and 3 years of Scientific experience
OR
Bachelor's degree and 5 years of Scientific experience

Preferred Qualifications:

Bachelors in a pharmaceutical science, analytical chemistry or equivalent field of study.

Effective oral and written communication skills.
3+ years of drug discovery experience.

Basic understanding of ADME science and hand-on experience with bio-sample handing and quantitative LC/MS/MS assay.

Critical thinking and demonstrated ability to communicate with team members across broad disciplines.

We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.