R&D Specialist

Location
Tarrytown, NY, United States
Posted
Sep 24, 2019
Ref
17665BR
Required Education
Bachelors Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
We are seeking a research associate to work in our Protein Development group. This position will be focused on preparation of proteins to support the efforts of Regeneron's structural biology group in X-ray crystallography and cryo-electron microscopy (cryoEM). The successful candidate will work closely with scientists in the structural biology group to develop purification procedures to deliver highly pure and homogeneous protein samples.

Responsibilities:
This work will be directed toward supplying the structural biology group with proteins or protein complexes for their research. In some cases, the purification procedure will be straightforward, previously tested in house or in the scientific literature, in which case the priority will be to execute the procedure as cleanly and carefully as possible, so that the resulting sample will be pure and homogeneous, raising the odds of a successful structure determination.

However, in many cases, there will be no clear path to follow. In these cases, the individual in this position will need to collaborate with the structural biology scientists to develop a new purification procedure, drawing on available literature and previous experience, but then breaking new ground and using results from first attempts to refine the procedures for the next attempts. In the most challenging cases, we will be attempting things that may have never been done before.

The proteins to be purified will be very diverse, giving the position holder a chance to learn and experiment with a wide variety of cutting-edge purification techniques, including automated purification method development, high-throughput capillary electrophoresis, and SEC-MALS.

Although mammalian and insect cell protein expression will be performed by other groups, this position offers the opportunity to carry out some bacterial protein expression as well, in collaboration with Protein Development scientists.

Requirements:
Candidates should have a minimum of a bachelor's degree with 2-3 years of directly relevant protein purification experience. Prior experience in protein crystallization or cryoEM sample preparation is not required, but would be helpful.

The successful candidate should have a track record of protein purification in a variety of projects. The structural biology samples to be worked on in this position will come from different expression systems, including bacteria, insect cells, and mammalian cells, and will include both soluble and membrane proteins. A candidate with experience across this spectrum will be preferred, although we do not expect any one person to have done all of this.

The candidate should have experience with most standard protein purification techniques, including size-exclusion, ion exchange, and affinity chromatography, and protein characterization by SDS-PAGE and Western blotting.

This position will involve work on multiple projects simultaneously, so excellent record-keeping and time management skills are very important, as well as the ability to absorb new information rapidly. The candidate should be highly self-motivated and capable of working independently with suitable guidance. Familiarity with lab database and LIMS systems will be an advantage.

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This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.