Scientist I, Translational Research in Imaging
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Sep 22, 2019
View more
- Discipline
- Regulatory, Science/R&D, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
KEY ROLES/RESPONSIBILITIES-THIS POSITION IS CONTINGENT UPON FUNDING APPROVAL
- Develop and validate imaging approaches for multiplex immunofluorescence assays on state-of-the-art whole slide imaging platform in support of clinical studies and initiatives
- Responsible for mastering novel imaging technology, software and instrumentation
- Management of large data sets generated from image acquisition platform
- Data analysis of immunofluorescence assay studies on fixed xenograft tissue sections and clinical specimen biopsies using advanced quantitative image analysis software
- Design, test and write detailed technical SOPs for imaging and analysis for transfer to external labs
- Generate materials and data necessary to support the primary experimental objectives of the program
- Design, perform, analyze, and present in vitro experiments to test pharmacodynamic marker responses to novel anti-cancer therapeutics in multiple formats, but particularly in multiplex immunofluorescence analysis
- Support development and implementation of multiplex immunofluorescence assays in support of clinical studies and initiatives on flow cytometry and microscopy platforms
- Design experiments and strategies to test and confirm putative mechanism of action of clinical trial candidate compounds
- Perform laboratory analysis, data analysis and reporting of results from specimens obtained from patients enrolled in clinical trials to the NCI
BASIC QUALIFICATIONS
- Possession of a Doctoral degree from an accredited university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
- No experience beyond the doctorate is required
- Demonstration of specific training in cancer biology, biomarker development, or drug screening strategies is required
- Experience in the design and validation of multiplexed immunofluorescence assays and the ability to work across testing platforms during the assay development process
- Experience with quantitative image analysis software
- Experience with flow cytometry, imaging flow cytometry
- Design of in vitro, cell-based assays to test mechanism of action of candidate compounds
- Ability to master novel technologies and instrumentation in response to changes in project priorities or breakthrough technological innovations; hands-on instrumentation work is required for this position
- Ability to communicate with program lead researchers in a demanding scientific environment through preparation of formal reports is essential
- pharmacology; cancer biology; flow cytometry; high content image analysis; immunofluorescence microscopy
- Ability to maintain precise records
- Must be able to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
- Experience with advanced imaging instrumentation, software and technologies
- Experience with tissue-based immunofluorescence assays
- Statistical analyses approaches
- Data management
- Experience in isolation and characterization of individual target cells
- Experience with circulating tumor cell or T cell subset analysis
- A record of publication in refereed scientific literature
- Completion of related post-doctoral research and/or training
JOB HAZARDS OR REQUIREMENTS
- Candidate will be working with or have the potential for exposure to animal(s) and/or animal material(s)
- Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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