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Research Associate - Formulations

Employer
Precision BioSciences, Inc.
Location
Durham, NC, United States
Start date
Sep 20, 2019

View more

Discipline
Science/R&D, Biotechnology, Research
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Bio NC

Job Details

Assist in design and execution of experiments to provide support for mRNA process development and lipid nanoparticle formulations for research applications using ARCUS nucleases.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.
  • Formulate in-house lipid nanoparticle formulations containing nucleic acids
  • Assess formulations and mRNA for quality, potency and toxicity
  • Generate and compile analytical data used to issue certificate of analysis (CoA) for each batch of lipid nanoparticles before use in research applications
  • Provide formulations with ARCUS nucleases to research teams for non-clinical studies
  • Maintain cell lines for use in research studies and assist in general operation of the cell culture and molecular lab
  • Maintain accurate records in Electronic Lab Notebook (ELN) system and assist in the organization and tracking of formulations; write reports and communicate results to the Formulation team
  • Maintain lab equipment, including calibrations, log books and general cleaning of glassware; order lab supplies and maintain consumables as needed
  • Prepare sterile filtered buffers, reagents and formulations as well as assess sterility of prepared solutions (endotoxin assay)

Qualifications
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Education/Experience

Required:
  • BS in chemistry, biology, or engineering, or equivalent, with a minimum of 4 years related lab experience and/or training or Masters degree with 2 years related lab experience
  • Extensive experience with aseptic techniques
  • Extensive experience in maintaining adherent and suspension cell lines
  • Extensive experience performing 96 well based assays

Preferred
  • Experience with culturing of primary cell lines
  • Experience with lipids and lipid based nanoparticles for nucleic acid delivery
  • Experience with PCR, ddPCR, gel electrophoresis, and indel analysis as well as nucleic acid (mRNA and pDNA) production (amplification, purification, characterization)

Travel Requirements
  • This position may require occasional travel

Precision BioSciences is dedicated to improving life through its proprietary genome editing platform, ARCUS. Precision BioSciences leverages ARCUS in the development of its product candidates which are designed to treat human diseases and create healthy and sustainable food and agriculture solutions. Precision BioSciences is actively developing product candidates in three innovative areas: allogeneic CAR T immunotherapy, in vivo gene correction, and food.

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

Company

Precision BioSciences, Inc. (Nasdaq: DTIL) is a clinical stage gene editing company developing in vivo gene editing and ex vivo allogeneic CAR T therapies with its highly precise and versatile ARCUS genome editing platform. ARCUS uses sequence-specific DNA-cutting enzymes, or nucleases designed for gene knock out, as well as highly sophisticated edits for gene insertion and/or gene repair. Precision’s in vivo gene editing pipeline consists of wholly-owned preclinical candidates for primary hyperoxaluria type 1 (PBGENE-PH1), familial hypercholesteremia (PBGENE-PCSK9) and chronic hepatitis B (PBGENE-HBV). It has also partnered with Lilly to develop candidates for Duchenne muscular dystrophy and two other programs targeting the liver and CNS. Precision’s allogeneic CAR T pipeline consists of multiple investigational candidates in early-stage clinical trials, including its first and second generation CD19 targeting candidates PBCAR0191 and PBCAR19B for relapsed and/or refractory (R/R) non-Hodgkin and B-cell lymphoma patients. Precision has also prioritized development of PBCAR269A, its BCMA targeted candidate in combination with a gamma secretase inhibitor for R/R patients with multiple myeloma. Precision BioSciences and its in-house manufacturing facility for AAV, mRNA, and CAR T cells is based in Durham, North Carolina. For more information about Precision BioSciences please visit www.precisionbiosciences.com

Stock Symbol: DTIL

Stock Exchange: NASDAQ

Company info
Website
Phone
919-314-5512
Location
302 East Pettigrew Street
Durham
North Carolina
27701
US

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