NGS Data Analyst, Regeneron Genetics Center

Location
Tarrytown, NY, United States
Posted
Sep 14, 2019
Ref
17551BR
Discipline
Science/R&D, Genetics
Required Education
Bachelors Degree
Position Type
Full time
The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

Summary:
The NGS Data Analyst will assist in the maintenance of the Regeneron Genetic Center's sequencing production pipeline on a combination of on-premise and cloud computing platforms. Furthermore, the candidate will track samples throughout the pipeline, and investigate and troubleshoot inconsistencies when necessary. Strong communication skills are highly desirable, as the candidate must interface with other analysts as well as laboratory personnel.

Responsibilities:

• Assist with daily maintenance of sequencing production pipeline

• Communicate and collaborate with wet lab personnel, LIMS team, and instrument support staff to facilitate and coordinate production throughput

• Troubleshoot and quality control of production throughput

• Track samples and metadata in a high throughput production environment

• Review production pipelines, investigate anomalies and inconsistencies, communicate with colleagues and devise a plan for mitigation.

• Collaborate and partner with the software vendors (such as DNAnexus) to troubleshoot, request features, and plan for future changes

• Assist in the generation of analyses and implementation for non-production, non-standard sequencing projects.

• Validation of new bioinformatics workflows, and interpreting results

Requirements:
  • Bachelors in bioinformatic, life science or similar with minimum 1-3+ years relevant experience
  • Deep problem solving of informatics pipelines as it relates to wet lab procedures
  • Unix, python
  • Experience in high throughput computing (DNAnexus or other cloud experience preferred).
  • Effective communication and interpersonal skills
  • Ability to learn, understand and integrate software packages

Preferred Skills:
Familiarity with NGS tools (Samtools, BCFtools, VCFtools, BWA, GATK, Picard, BEDtools, PLINK)

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.