Bristol-Myers Squibb Company

Senior Research Investigator Genomics

Location
Princeton, NJ, United States
Posted
Sep 13, 2019
Ref
R1514361
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide ouremployees the resources to pursue their goals, both at work and in their personal lives.

We are seeking a highly motivated molecular biologist to join our Discovery Genomics team.

The Genomics group provides experimental support for Immuno-Oncology, Immunoscience, Fibrosis and Cardiovascular treatment areas in pre-clinical models and translational studies for first-in-human trials. The successful candidate will help advance Bristol-Myers Squibb's industry leading pipeline by using genomics to provide critical data on mechanisms of action, pharmacodynamic effect and to generate patient stratification hypotheses. Additionally, the candidate will adapt or develop novel laboratory methods in genomics to answer key questions in disease pathology or drug activity.

This role will have two major responsibilities: devising and executing genomic assays (mainly RNA-Seq) to help drug programs advance and identifying, then implementing new genomic technologies. One focus of technology development is piloting methods to use imaging in conjunction with transcriptomics/proteomics to characterize the activation states of immune cells for formalin fixed, paraffin embedded (FFPE) tissues. Another focus is integrating proteomics and transcriptomics to explore rare immune cell types and phosphorylation states.

Responsibilities

Design and oversight of RNA-Seq and other genomics experiments to ensure actionable and timely data is being generated for Discovery programs.

Development and automation of methods for integrated molecular characterization: co-extraction of proteins, DNA and RNA with sufficient quality to enable NGS and mass-spectrometry based proteomics.

Implementation and improvement of FFPE RNA-Seq/DNA-Seq library preparation methods. Automation of macro/micro-dissection and other spatially resolved transcriptomic methods.

Bioinformatic analysis of genomics data for quality control and method development.

Supervision of 2-3 experienced associate scientists (depending on the candidate).

Qualifications

Ph.D. in biology or similar discipline with 3-6 years of experience.

Experience in using genomics and bioinformatics to understand disease mechanisms and test hypotheses.

Deep understanding of next-generation sequencing methods: from experimental design to library preparation and sequencing instrumentation.

Evidence of scholarship in at least one of the following human disease areas: cancer, immunology, fibrosis or cardiovascular.

Expertise in handling and analyzing FFPE tissue: sectioning, immunostaining, RNA extraction, and interpretation of images.

Ability to communicate effectively with biologists, biostatisticians and computational scientists.

Experience in laboratory automation and ability to use R for data analysis is highly desirable.

Previous experience in a pharmaceutical drug discovery or biotechnology industry a plus but not required.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.