Formulation Scientist/Technician (Part time)
- Employer
- Principia Biopharma
- Location
- South San Francisco, California, United States
- Start date
- Sep 12, 2019
View more
- Discipline
- Science/R&D, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Contract
- Hotbed
- Biotech Bay
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About Principia:
Principia is a late-stage biopharmaceutical company focused on developing novel therapies for immune mediated diseases. Principia's proprietary Tailored Covalency® platform differentiates the company's investigational therapies from traditional small molecules and provides the potential to deliver the potency, selectivity and safety of injectable drugs while maintaining the convenience of a pill. This highly reproducible approach enables the company to pursue multiple programs efficiently. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 3 clinical trial in patients with pemphigus, an orphan autoimmune disease, and in a Phase 1/2 clinical trial in patients with ITP. PRN2246/, a covalent BTK inhibitor that crosses the blood-brain barrier, is being evaluated in a Phase 2 clinical trial in patients with multiple sclerosis and has been partnered with . PRN1371, a covalent inhibitor of Fibroblast Growth Factor Receptor (FGFR) is being evaluated in a Phase 1 trial in patients with bladder cancer.
Responsibilities:
Hours: approximately 20 hours per week to start, may increase depending on increasing level of responsibilities
Education/Experience/Skills:
Principia Biopharma is an equal opportunity employer.
Principia is a late-stage biopharmaceutical company focused on developing novel therapies for immune mediated diseases. Principia's proprietary Tailored Covalency® platform differentiates the company's investigational therapies from traditional small molecules and provides the potential to deliver the potency, selectivity and safety of injectable drugs while maintaining the convenience of a pill. This highly reproducible approach enables the company to pursue multiple programs efficiently. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 3 clinical trial in patients with pemphigus, an orphan autoimmune disease, and in a Phase 1/2 clinical trial in patients with ITP. PRN2246/, a covalent BTK inhibitor that crosses the blood-brain barrier, is being evaluated in a Phase 2 clinical trial in patients with multiple sclerosis and has been partnered with . PRN1371, a covalent inhibitor of Fibroblast Growth Factor Receptor (FGFR) is being evaluated in a Phase 1 trial in patients with bladder cancer.
Responsibilities:
- Develops and prepares formulations for compounds in discovery and development
- Conducts experiments to determine physical and chemical properties of compounds in discovery and early stages of development
- Support oral dosage formulation development and physical characterization activities
- Support analytical related activities including method development, operation and maintenance of HPLC and dissolution testing apparatus
- Meets with research groups for project meetings and prepares data for presentation.
Hours: approximately 20 hours per week to start, may increase depending on increasing level of responsibilities
Education/Experience/Skills:
- PhD in pharmaceutics or related with 0-1 year industry experience
- MS or BA degree in related scientific discipline with 3+ years industry experience
- Experience in Biotech/Pharmaceutical industry preferred
- Must have proven skills in the areas of formulation experience in developing oral and IV dosing solutions for preclinical studies
- Experience with analytical instrumentation
- Hands on experience in HPLC, dissolution
- Strong interpersonal, communication, and collaboration skills along with strengths in delivering results on firm deadlines in support of discovery/development programs.
- Thinks critically and creatively and is able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
Principia Biopharma is an equal opportunity employer.
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