Principal Scientist, Translational Medicine

Employer
Kite Pharma
Location
Santa Monica, CA, United States
Posted
Sep 11, 2019
Ref
R0008405
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
Kite, a Gilead Company, is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel cancer immunotherapy products designed to harness the power of a patient's own immune system to selectively target and kill cancer cells. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

Do you want to make a real difference in the world? Come help us in our quest to cure cancer! Everyone at Kite is grounded by this common goal. Every single day, we seek to establish a direct line between that purpose and our day-to-day work. Join us in our mission!

We are seeking a self-motivated and ambitious person with a strong work ethic to join us as a Principal Scientist within the Department of Translational Medicine (TM). In this position, you will work with the TM team to directly support clinical development of Kite's chimeric antigen receptor (CAR-T) oncology programs. The successful person will aid in the design and execution of translational strategy pivotal to Kite's CAR-T pipeline and aid in reverse translational initiatives (bedside to bench). A demonstrated ability to support clinical trial execution, synthesize scientific data and communicate key findings cross-functionally is required. You will also be asked to perform other duties as required to support Kite's pipeline development.

Key Responsibilities:
  • Support design of CAR T clinical trial pharmacology and discovery biomarker strategy
  • Serve as TM lead and oversee delivery of key pharmacology data deliverables required for registrational studies (pharmacodynamic, pharmacokinetic, safety related and detailed product characterization information)
  • Work with Clinical Data Management and Biometrics to qualify data acquisition and aid in interpretation of analyses of clinical trial data
  • Support the preparation of data packages for publication, presentation and/or submission to regulatory agencies
  • Contribute to company-wide and external scientific discussions and engagement with key opinion leaders in the field
  • Identify and establish agreements with contract research organizations (CRO) and support the transfer of novel methods
  • Supply to internal technology evaluation, development, qualification, and execution of innovative assays for clinical biospecimen monitoring
  • Write, review, and edit technical documents including SOPs, development/qualification of protocols and drafting of study reports
  • Support globally regulatory requests including Investigational New Drug (IND), Biologics License Application (BLA) and other key global regulatory filing activities
  • Other duties as applicable


Requirements:
  • PhD degree with demonstrated experience in cell therapy, immunology, cancer biology or a closely-related field and 5+ years of industry or meaningful experience
  • Familiarity in the areas of cell therapy, immunology, immuno-oncology and cancer biology
  • Understanding of basic CAR-T cell pharmacokinetic and pharmacodynamic studies
  • Previous clinical trial experience in the setting of translational biology desirable
  • Experience with relevant diagnostic technologies with an emphasis on flow cytometry, multiplexed immunoassay, and PCR methods
  • Knowledge of scientific applications such as GraphPad Prism, FlowJo, FACSDiva and Spotfire are highly desirable
  • Experience with clinical biospecimen testing, assay development and qualification
  • Knowledge of laboratory information management system (LIMS) and electronic lab notebook record keeping (ELN)
  • Strong personal leadership, interpersonal and record-keeping skills
  • Excellent social, verbal and written communication skills are essential in this reciprocal work environment
  • Comfortable in a dynamic environment and able to adapt to changing priorities
  • Self-motivated and ambitious person with a strong work ethic


#LI-MO1

#IND123

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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