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Lead Scientist, In Vitro Screening Science and Automation

Employer
Frederick National Laboratory for Cancer Research
Location
Frederick, MD, USA
Start date
Sep 11, 2019

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Discipline
Engineering, Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
BioCapital
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Job Details

The Molecular Pharmacology Branch (MPB) mission is to improve the treatment of recalcitrant, rare and neglected cancers through the identification of potential targets, the screening of new and known agents, the identification of genomic vulnerabilities and the identification of potential therapeutic combinations using state-of-the-art molecular characterization, mechanism-of-action techniques. In support of this mission, the MPB operates four laboratories at the National Cancer Institute-Frederick campus. While the Translational Support Laboratory is a federal laboratory, the other three laboratories are operated by the contractor that holds the Frederick National Laboratory for Cancer Research (FNLCR) contract with the NCI (currently Leidos Biomedical Research, Inc): the NCI60 Screening Laboratory, the In Vitro Screening Laboratory, and the Molecular Pharmacology Laboratory.

KEY ROLES/RESPONSIBILITIES

The Lead Scientist will:
  • Serve as the scientific lead for the NCI60 screening and the Target Validation and Screening labs
  • Work with and lead teams to develop new screening techniques, discover compound hits, and to contribute scientifically to projects
  • Write scientific articles and patents and present data at relevant national and international meetings
  • Serve as the main contact point for multi-disciplinary project teams for both initial compound screening and validation and testing of SAR compounds
  • Lead a group of 6-8 technicians/scientists with direct responsibility for their management, motivation, and career development

BASIC QUALIFICATIONS
  • Possession of a Doctoral degree to include (e.g., D.V.M., D.Sc., M.D., Ph.D.) from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in a related field (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to educational requirements, a minimum of eight (8) years of post-graduate experience including five (5) years of independent, competent, and innovative research in a field of specialty
  • Three (3) or more years of managerial experience is required
  • Must be an excellent team player with well-documented leadership skills
  • Excellent communication, troubleshooting, and organizational skills required
  • Candidates should be forward-thinking with exceptional problem-solving skills and of the highest integrity
  • Must be able to obtain and maintain a clearance

PREFERRED QUALIFICATIONS
  • Experience in high throughput screening
  • Good understanding of enzyme kinetics
  • Knowledge of protein-protein interactions
  • Prior industry/ biotech experience
  • Leadership skills
  • Excellent communication, troubleshooting and organizational skills

Expected Competencies:
  • Must have in-depth knowledge and expertise in target identification and validation, high, medium and low throughput screening assay design and development, hit confirmation, data mining, robotics and screening automation, and a good understanding of enzyme kinetics and protein-protein interactions
  • Experience in executing biochemical, cell-based, siRNA as well as high content screening campaigns for varied target classes
  • Hands-on experience in data processing, data reduction and analysis, and a solid expertise in interrogating, interpreting, and summarizing large volumes of data with adequate reporting and statistical analysis and respect for timelines
  • Must have a good understanding of enzyme kinetics

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

Company

A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take

 

 

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Company info
Website
Phone
301-846-1000
Location
8560 Progress Drive
 Frederick
MD
21701
US
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