Pharmacyclics, LLC

Scientist II, PK Modeling

Sunnyvale, CA, United States
Sep 10, 2019
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

General Position Summary/Purpose:

The Drug Metabolism, Pharmacokinetics & Translational Modeling Department at AbbVie, Inc. is seeking a scientist to assist in the design and analysis of pre-clinical pharmacokinetic studies of both small and large molecules. The position will be located for the near future at the AbbVie/Pharmacyclics site in Sunnyvale and long term at the AbbVie South San Francisco site. The scientist will partner with drug discovery and development teams, including the in vivo team, to assist in study scheduling, study design, logistical coordination and pharmacokinetic data processing.

Key Accountabilities/Core Job Responsibilities:

  • Support project teams in the study design and scheduling of pre-clinical in vivo studies of both small and large molecules across multiple therapeutic areas including Oncology, Immunology and Neuroscience.
  • Collaborate with cross-departmental team members including Toxicology, Pharmaceutics and Compound Management to ensure seamless and timely execution of in vivo pharmacokinetic studies.
  • Process data, perform pharmacokinetic calculations, interpret PK profiles, summarize in report format and distribute to project teams.
  • Partner with senior staff to maintain and update IACUC protocols
  • Assist in the preparation of DMPK-BA sections of IB and IND.


  • BS with typically 7 or more years of experience or MS with typically 5 or more years of experience in the pharmaceutical industry.
  • Experience with software such as Phoenix WinNonlin, TIBCO Spotfire and electronic laboratory notebooking systems is required.
  • Highly motivated individual with attention to detail and a proven ability to work cross functionally.
  • Ability to work well in a collaborative fast-paced team environment.
  • Passion for data analysis, solving technical problems and applying new technologies to further scientific goals.


Equal Opportunity Employer Minorities/Women/Veterans/Disabled