Senior Scientist I/II, In Vivo Pharmacology, Parkinson's Disease

Cambridge, MA, US
Sep 08, 2019
Required Education
Position Type
Full time
AbbVie is investing heavily in a new research enterprise in Cambridge, Boston - the Foundational Neuroscience Center (FNC). The FNC will investigate the fundamental biological mechanisms underpinning neurodegenerative disease, especially Alzheimer's disease.

AbbVie is seeking an experienced, highly motivated, lab-based Senior Scientist with experience working with biologics and small molecules in preclinical models of Parkinson's disease to join the FNC In Vivo Pharmacology team. The successful candidate will independently design and implement experiments to address target engagement, mechanisms-of-action and efficacy of therapeutic molecules.

Key Responsibilities Includes:
  • Design and interpret in vivo pharmacology studies to evaluate the activities of biologic drug candidates including PK/PD characteristics, target engagement, mechanisms of action and efficacy
  • Collaborate with key internal and external scientists to drive improved understanding of disease pathophysiology and target biology
  • Oversee interactions with contract research labs and academic institutions for preclinical studies, including lab selection, protocol development, oversight and review of final report
  • Train and manage direct reports

Position will be hired based on level of experience.
  • PhD in Neuroscience or related field with 0-4+ years of academic or industry research experience; MS with 8-10+ years of experience; BS with 10-12+ years of experience.
  • Must have experience designing and conducting in vivo pharmacology studies with in animal models of Parkinson's disease
  • Excellent in vivo skills (dosing, tissue/fluid harvest) and prior experience doing biochemical and/or histological analysis required
  • Experience in standard molecular biology and protein biochemistry techniques (e.g. protein purification, ELISA, WB) is also highly preferred
  • Outstanding organizational and critical thinking skills
  • Excellent verbal and written communication and interpersonal skills to work across functions and across sites, and within academic collaborations