Senior Scientist II/III, In Vivo Pharmacology

South San Francisco, CA, US
Sep 08, 2019
Required Education
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, statisticians, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immunooncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie's South San Francisco oncology site.

The In Vivo Pharmacology Department is searching for a Senior Scientist II/III who will lead Pharmacology strategy and operations. The role expectations involve working collaboratively across DMPK, projectbased teams, and biological discovery teams to formulate the in vivo efficacy strategies for various oncology programs and new in vivo research initiatives. Additionally, the candidate will be responsible for hypothesis generation and testing. They will then coordinate efficacy analyses for communication to other teams via presentations and/or reports. The ability to work independently and efficiently on multiple responsibilities and effectively participate and communicate as part of the team is required.

  • Lead Pharmacology functions within In Vivo Pharmacology team, including oncology mouse model establishment and oversight of in vivo study operations, strategy, and quality control
  • Contribute Pharmacology strategy and prepare data analyses presentations at meetings for multiple projects
  • Work across discovery teams to integrate efficient workflows and develop new research initiatives for in vivo models and study designs
  • Evaluate and contribute improvements to existing Pharmacology workflows, data entry/visualization tools, and strategies
  • Ensure Pharmacology operations are aligned and in compliance with institutional animal research protocols, training, and animal welfare recommendations
  • Management and mentoring of 1-2 direct reports

  • PhD in Molecular & Cell Biology, or a related discipline, with 4+ (Senior Scientist II) or 6+ (Senior Scientist III) years of relevant research experience preferably in a Pharmaceutical or Biotechnology industry setting
  • Hands-on experience with strategy development and detailed in vivo study designs,integrating PK, historical perspective, and translational considerations
  • Extensive knowledge of oncology models, including patient-derived and cell line-derived xenograft models, and genetically engineered mouse models
  • Experience with pharmacodynamics endpoints, such as biomarkers or in vivo imaging, is a plus
  • Scientific leadership abilities and collaborative personality
  • Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills
  • Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment
  • Dedicated to mentoring and fostering career development opportunities in direct report and other team members
  • Raises the bar and is never satisfied with the status quo
  • Excited to participate in and contribute to company culture