Senior Scientist - Computational Biology

South San Francisco, CA, US
Sep 08, 2019
Required Education
Bachelors Degree
Position Type
Full time
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing our Translational Science focus with modern molecular and cellular science and pathology laboratories, designed to discover and develop valuable biomarkers in support of clinical programs.

The Clinical Biomarkers & Diagnostics department at Amgen is looking for a highly motivated Computational Biologist with expertise in statistical modeling, handling clinical data sets and a background in biology. The primary responsibilities would be to support biochemical coverage, patient stratification, indication selection in Amgen's early clinical development programs. The job will involve working with biologists especially in immuno-oncology to leverage information on our targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics, GWAS, next-generation sequencing and other high-content databases. The candidate is expected to interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives. As such, strong communication skills are imperative. Data integration, management, visualization, analysis and presentation are anticipated to be a substantial component of this job and the candidate is expected to provide leadership and expertise in those domains.

Basic Qualifications

Doctorate degree and 2 years of scientific experience


Master's degree and 5 years of scientific experience


Bachelor's degree and 7 years of scientific experience

Preferred Qualifications

PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Biology

A working knowledge of applied mathematics or statistics to analyze large-scale biological data sets such as those from GWAS or Next-generation sequencing platforms

Ability to translate biological and medical questions into analytical models providing actionable results

Programming experience in scripting languages such as Matlab

Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers

Familiarity with assay development and qualification requirements for clinical trial support

In depth understanding of genomic technologies such as, but not limited to, next generation sequencing and transcriptional profiling in clinical samples

Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community.

Outstanding communication skills including both oral and written presentation

Enjoys working in collaborative team environment

Record of establishing and leading lead cross-functional teams

Three or more years of relevant experience in the biotech or pharmaceutical industry

A strong scientific background with training I n genetics and a proven track record of productivity

Strong written and oral communication skills, self-motivation, independence and leadership

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:
  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.