Research Scientist, Translational Medicine

Kite, a Gilead Company, is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel cancer immunotherapy products designed to harness the power of a patient's own immune system to selectively target and kill cancer cells. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

Do you want to make a real difference in the world? Come help us in our quest to cure cancer! Everyone at Kite is grounded by this common goal. Every single day, we seek to establish a direct line between that purpose and our day-to-day work. Join us in our mission!

Research Scientist, Translational Medicine

(Research Scientist, Cell Biology)

We are seeking a highly motivated Scientist to join us in the Translational Medicine department. You will generate and use translational data in the context of clinical studies, leading to impactful evidence and insights on our cellular therapy programs to advance mechanistic understanding of efficacy and toxicity of T cell immunotherapies.

You will have the primary responsibility to generate data utilizing a variety of assays conducted internally or outsourced, and design and implement analyses using a variety of data sources. These include but are not limited to clinical data, pharmacokinetics & pharmacodynamics readouts, product attributes, next-generation sequencing data. The insights generated will be utilized to inform our research and development efforts. This will require a solid biology background including immunology or oncology, complemented by some computational background in disciplines such as data science, statistics, machine learning, or bioinformatics. Experience with single cell genomics or proteomics analysis is highly desirable. You will need strong strategic, collaborative and communication skills to transform the way we use data and analytics to advance our pipeline.

Responsibilities

• Generate and analyze translational data including single cell genomics / proteomics, internally or through managing external projects.
• Leverage computational analysis strategies across a variety of biological, clinical, and manufacturing data to drive decisions in the development of next-generation cellular therapies.
• Develop integrative analysis strategies and identify relationships between manufacturing process, product attributes (such as molecular/cellular phenotypes, cellular functional assays), patient characteristics, and clinical trial results.
• Manage and structure large, complex data sets such RNA-seq, ATAC-seq, single cell sequencing, and high dimensional flow cytometry.
• Collaborate with colleagues in translational medicine, biometrics, process development, and research by providing data analytics expertise.
• Stay current with and adopt emerging analytical methodologies, tools and applications to ensure fit-for-purpose and impactful approaches.
• Communicate findings to internal stakeholders, publish results, and participate in external meetings and forums.
• Contribute to strategic collaborations with academic and commercial partners.

Requirements

• PhD or equivalent, with laboratory experience in immunology, genetics or oncology areas.
• Experience with single cell genomics / proteomics and quantitative data science discipline (bioinformatics, computational biology, statistics, computer science, or related field)
• Familiarity with coding, R and at least one additional programming language (Python, etc.), machine learning approaches.

• Strong team player, excellent organization and communication skills as well as strong problem solving and analytical skills
• Proficiency in English, both written and verbal

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Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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