Eli Lilly and Company

Research Scientist-Immune Cell Redirection Drug Development

New York, NY, United States
Aug 23, 2019
Required Education
Associate Degree
Position Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.



Lilly's Immuno-Oncology Research and Development Center of Excellence in New York City is expanding its capabilities in the Immuno-Oncology arena. We are seeking a highly motivated scientist to contribute to the development of cancer therapeutics in the Cancer Immunobiology department. The ideal candidate is expected to have a broad knowledge of cancer immunology with prior academic and/or industry experience and publications in the field.

You will be responsible for leading a group of associate scientists to support drug discovery and development in the area of T cell redirection within the immune oncology discovery area at the Lilly NY laboratories. Additional responsibilities will be in contributing to novel redirection strategies as well as the overall Immuno-Oncology portfolio. Both target identification and target validation work will be required, including independently crafting and carrying out experiments, directly overseeing Research Associates in their day-to-day work, and collaborating with broader Lilly resources in a matrixed fashion to achieve goals. Ultimately it is expected that drug candidates will be carried into clinical development. This role involves both coordinating laboratory experiments as well as performing laboratory experiments which are designed to understand the mechanism of action of pipeline cancer therapeutics. Examples include but are not limited to
  • developing and performing in vitro and in vivo models and assays;
  • mammalian cell culture (primary immune cell isolation/culture), transfections, stable clone generation; flow cytometry and immunophenotyping;
  • cell based and immunological assays including proliferation, effector function, reporter assays, T cell activation, antigen specific T cell isolation and characterization, T cell tumor killing.

You would also function as scientific team lead and contribute to project team meetings providing written and verbal communication of work, presentation of data and data summaries internally and externally as needed.

Do you have a broad understanding of basic immunology as well as cancer immunobiology? This includes expertise in aspects of T cell priming, expansion and suppression. Experience in the area of T cell redirection is essential. You should also have expertise in mechanisms of tumor mediated immune suppression. You should have the ability to communicate well both verbally and written. Collaboration and teamwork are cornerstones of our research requiring you to work independently as part of a multi-disciplinary team and to collaborate across functional areas.

Basic Qualifications
  • PhD in Biological Sciences (e.g. Immunology, Tumor Immunology, Cell Biology or closely related scientific field of study).

Additional Skills/Preferences
  • Prior post-doctoral and/or industry research experience in the Immuno-Oncology setting highly preferred.

Additional Information
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.