Senior Scientist II, Downstream, Manufacturing Sciences

We are seeking a highly motivated Senior Scientist II to join our Downstream group in the Manufacturing Sciences department at AbbVie Bioresearch Center based in Worcester, MA. As part of the Manufacturing Sciences organization, our group leads the downstream process optimization, validation, implementation, continuous improvement and global technical support for late-stage and commercial manufacturing of therapeutic proteins for AbbVie. We also provide manufacturing support and author regulatory filing CMC sections.The candidate should have extensive experience and comprehensive knowledge in protein purification unit operations, process characterization, and process validation, including antibody-drug conjugate (ADC) technology. The candidate is expected to devise and implement protein purification strategies to solve complex challenges across the AbbVie pipeline, including ADC. The candidate is expected to manage direct reports and productively lead several projects simultaneously in a dynamic and rapidly evolving project landscape.

Key Responsibilities Include:

• Lead team on the design, execution, and data-analysis for process development, characterization, optimization and validation, including ADC
• Identify, evaluate, and develop innovative technologies within the field of downstream processing to improve product quality, and process efficiency and robustness, including ADC
• Lead team on technology and process transfer to pilot scale and GMP plants of therapeutic proteins, including ADC
• Solve technical issues and support GMP manufacturing of therapeutic proteins, including ADC
  Participate in cross-functional teams and author/review/defend CMC sections of regulatory filings
• Author technical reports and validation documents
• Interact with cross-functional groups (e.g. discovery, process sciences, manufacturing, quality, and regulatory)
• Author peer-reviewed articles and patents and present original work in conferences

• BS, MS, or PhD in Chemical or Biochemical Engineering, Biochemistry, or related field with typically 12+ years (BS), 10+ years (MS), or 4+ years (PhD) of relevant experience; pharmaceutical industry experience preferred
• Outstanding record of accomplishment in areas of purification bioprocess development, improvement, and validation, including ADC
• Ability to run downstream experiments in the laboratory, and to coach and supervise junior level scientists
• Deep knowledge of protein analytical methods
• Experience in managing technical professionals
• Strong written and oral communication skills
• Interacts well with diverse groups and maintains strong working relationships with internal, global, and external collaborators
• Demonstrated problem-solving skills and capability to overcome complexed issues
• Demonstrated success in coordinating and executing important projects to achieve business unit goals
• Must have a "results-oriented" work ethic and a positive "can-do" attitude with a strong sense of urgency and self-motivated desire to achieve