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Senior Scientist / Associate Director \u0026 Head of Analytical Science

Employer
Nurix Therapeutics
Location
San Francisco
Start date
Aug 20, 2019

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Discipline
Information Technology, Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay
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Job Details

We are seeking a highly skilled and motivated analytical chemist to lead and grow a world class Analytical Group within Nurix. The successful candidate will support our entire research portfolio including small molecule, heterobifunctional protein-degradation, DNA encoded library, and DMPK teams. Capabilities in our analytical department include structure elucidation by NMR, extensive chromatography applications including SFC as well as identification and characterization of in vitro and in vivo metabolites. We are expecting this individual to add additional capacity and capability to the existing platform.

The ideal candidate will:
  • Manage, supervise and grow our cutting-edge Analytical Group.
  • Work closely with the medicinal chemistry teams providing analytical and chromatography expertise in the areas of small molecule purification and separation of enantiomeric mixtures using our in-house analytical and preparative SFC capabilities.
  • Provide structural elucidation expertise to chemistry, DMPK, CMC, and DNA encoded library teams.
  • Troubleshoot and maintain instrumentation, manage instrument service agreements, and develop best practices for their use.
  • Develop medicinal chemistry-enabling assays such as kinetic/thermodynamic solubility, in vitro clearance, soft spot analyses, and metabolite ID.
  • Be an active member of our project teams by attending project and department meetings and summarizing data.
  • Monitor analytical activities of our CROs.
  • Participate in experimental design and data analysis.

Requirements:
  • Ph.D. in Analytical, Physical or Organic Chemistry with 5+ years of pharmaceutical/biotech industrial experience or MS with 10+ years of industrial experience.
  • Solid background in developing analytical methods for the purification, characterization, and testing of small molecules utilizing prep HPLC, NMR, and UPLC-MS is essential. Chiral SFC experience (analytical & preparative) is desirable.
  • NMR experience using 2D-NMR, 1 H-NMR, and 13 C-NMR experiments is desirable.
  • Utilization of MS for structure elucidation and ADME for the determination of in vitro and in vivo metabolite identification.
  • Ability to troubleshoot and repair HPLC, UPLC-MS and NMR instrumentation is essential.
  • Experience with solubility and chemical stability assessments desirable.
  • Excellent communication (oral and written), documentation (record keeping, lab notebook, reports), organization, and interpersonal skills is essential.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info
Website
Phone
415-660-5320
Location
1700 Owens Street
Suite 205
 San Francisco
California
94158
US
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