Scientist, Structural Biology

94025, Menlo Park
Aug 19, 2019
Required Education
Position Type
Full time

Pacific Biosciences is seeking a highly motivated macromolecular modeler for a position at the Scientist level.  The candidate will work within an interdisciplinary team to model macromolecular complexes, enzyme variants and their interactions with nucleotide analogs.  The candidate will be able to draw on data from a wide variety of sources including crystallography, kinetic characterization and single molecule studies.  She or he will use these data to both help design experiments that test mechanistic hypotheses and to design variants with desirable sequencing properties.   The individual will be working in a fast-paced environment interacting with scientists from a wide variety of backgrounds.  The title will be based on the selected individual’s experiences and determined at the offer stage.

Position Requirements:      

  • Education Requirement: PhD.
  • More than 3 years of experience in a postdoctoral, biotechnology or pharmaceutical industrial role is a plus.
  • Extensive experience with macromolecular modeling is required. 
  • Rosetta modeling software expertise is highly desirable.
  • Experience with analyzing information in databases, curating databases is desired.
  • Knowledge of protein design/folding principles would be beneficial.
  • Ability to work on several projects simultaneously.
  • Effective communication (written/verbal) and ability to work independently and collaboratively as part of a team are critical.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

To apply:  Please include a cover letter with your application.  Please answer the following questions at the end of the letter:

  1. Have you designed mutations using structural, biochemical and kinetic information? If yes, briefly describe.
  2. What molecular modeling software are you comfortable using?
  3. What was your PhD (and/or Postdoctoral) research on?
  4. What do you find interesting about protein engineering/design?
  5. Have you worked on protein:nucleic acid interactions?
  6. Are you comfortable writing scripts/querying databases? Please describe.
  7. What is the most interesting scientific problem you have dealt with so far?


All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.