Principal Scientist - Pharmacokinetics & Drug Metabolism

South San Francisco, CA, US
Aug 17, 2019
Required Education
Bachelors Degree
Position Type
Full time
The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel, effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The responsibilities of a PKDM Principle Scientist are to develop staff, lead scientific strategy across the PKDM department, and build relationship across functions within the larger Research organization. The responsibilities will include data interpretation, communication of results, and contribution to decision making on project teams in support of drug discovery and development, as well as impacting the external scientific community.

The candidate will be responsible for leading the quantitative analytical efforts across range of molecular entities in support of both drug discovery and early development programs. The candidate should also be able to assist in troubleshooting when instrument or assay problems arise.

Basic Qualifications

Doctorate degree and 3 years Scientific experience


Master's degree and 6 years Scientific experience


Bachelor's degree and 8 years Scientific experience

Preferred Qualifications

Possesses personal leadership qualities that inspire trust, respect, credibility and confidence of peers and colleagues

Skilled in analytical chemistry including but limited to ligand-binding assays and mass spectrometry

Hands on experience with lab LIMS systems, e.g. WATSON

Expertise in design and execution of pharmacokinetic studies

Independent problem-solver with critical thinking capabilities

Excellent oral and written communication skill

Proven ability to design and execute pharmacokinetic experiments to characterize and quantify critical ADME parameters

An excellent understanding of bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:
  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.