Translational Research in Circulating Tumor Cells
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Aug 13, 2019
View more
- Discipline
- Regulatory, Science/R&D, Research, Oncology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue. The program operates several advanced, specialized instrumentation for image analysis of tumor biopsies, circulating tumor cells, and activated Tcells for measuring drug effects in patients enrolled in clinical trials.
KEY ROLES/RESPONSIBILITIES
THIS POSITION IS CONTINGENT UPON FUNDING APPROVAL
The Scientist will:
- Generate materials and data necessary to support the primary experimental objectives of the program
- Design, perform, analyze, and present in vitro experiments to test pharmacodynamic marker responses to novel anti-cancer therapeutics in multiple formats, but particularly in multiplex immunofluorescence analysis of circulating tumor cells and activated T cells
- Support development and implementation of multiplex immunofluorescence assays in support of clinical studies and initiatives on flow cytometry and microscopy platforms
- Design experiments and strategies to test and confirm putative mechanism of action of clinical trial candidate compounds
- Perform laboratory analysis, data analysis and reporting of results from specimens obtained from patients enrolled in clinical trials to the NCI
BASIC QUALIFICATIONS
- Possession of a Doctoral degree from an accredited university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
- No experience beyond the doctorate is required
- Demonstration of specific training in cancer biology, biomarker development, or drug screening strategies is required
- Experience in the design and validation of multiplexed immunofluorescence assays and the ability to work across testing platforms during the assay development process
- Experience with quantitative image analysis software
- Experience with flow cytometry, imaging flow cytometry
- Design of in vitro, cell-based assays to test mechanism of action of candidate compounds
- Ability to master novel technologies and instrumentation in response to changes in project priorities or breakthrough technological innovations; hands-on instrumentation work is required for this position
- Ability to communicate with program lead researchers in a demanding scientific environment through preparation of formal reports is essential
- Ability to maintain precise records
- Must be able to obtain and maintain a public trust security clearance
PREFERRED QUALIFICATIONS
- Experience in isolation and characterization of individual target cells
- Experience with circulating tumor cell or T cell subset analysis
- A record of publication in refereed scientific literature
- Completion of related post-doctoral research and/or training
EXPECTED COMPETENCIES
- pharmacology; cancer biology; flow cytometry; high content image analysis; immunofluorescence microscopy
JOB HAZARDS OR REQUIREMENTS
- Candidate will be working with or have the potential for exposure to animal(s) and/or animal material(s)
- Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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