Senior Scientist I, DMPK Modeling

Lake County, IL, US
Aug 09, 2019
Required Education
Position Type
Full time
AbbVie is seeking a highly motivated scientist to join our DMPK and translational modeling team in North Chicago. The ideal candidate will have strong background and expertise in pharmacokinetics and translational modeling. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational sciences. The position will involve conducting mechanistic PBPK, human PK, and DDI projections to support Discovery and Development project teams, enabling compound progression from discovery to early stages of clinical development. You will also be expected to evaluate new technologies and approaches to support the mechanistic and translational understanding of drug disposition and drug-drug interactions. In addition, you will have opportunities to contribute to broader areas within DMPK by as your experience and expertise warrants.

Core responsibilities include:
  • Applying translational modeling concepts for small molecules to enable human PK projections
  • Evaluating novel in vitro tools and methodology to enable and improve prediction of human PK
  • Liaise with DMPK, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
  • Ability to clearly communicate internally and externally on topics related to human PK prediction and translational modeling/simulation is required
  • Keep up to date with emerging literature and science in modeling and in vitro approaches

Basic Qualifications:
  • PhD degree and experience with DMPK experiments and projects, through academic or industry work
  • Possess thorough theoretical and practical understanding of own scientific discipline
  • Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
  • Passion for data analysis, solving technical problems and applying new technologies to further scientific goals.
  • Experience in modeling software such as SimCYP, GastroPlus, MatLab/Simbiology, Phoenix, WinNonlin

Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality