Bristol-Myers Squibb Company

Senior Research Scientist

Location
Cambridge, MA, United States
Posted
Aug 09, 2019
Ref
R1515359
Required Education
Masters Degree/MBA
Position Type
Full time
Bristol-Myers Squibb R&D is a science-driven, passionate organization determined to discover, develop and deliver medicines that have the potential to transform the lives of patients and establish new standards of care in areas of high unmet need. Patients' needs and scientific discovery are our driving force. The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will position our scientific team in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. Our scientists will focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology therapies. These are significant challenges that will require innovative solutions from the biopharma, biotech and academic communities.

Roles and Responsibilities

We are seeking a Research Scientist, who has experience in studying immune oncology and immune checkpoint biology and working knowledge of mechanisms of resistance. The qualified candidate has extensive experience working with clinical specimens in terms of pre-sampling strategies for the isolation of DNA/RNA/Protein from a variety of sample types, frozen/FFPE/fresh tissue and PBMCs/plasma/serum etc. The qualified candidate will be able to evaluate, optimize and develop new assays across multiple platforms from genomics, transcriptomics and proteomics to liaise with our emerging technology translational medicine teams in support of translational research activities. It is also expected that the ideal candidate would contribute scientifically to be objective and rationale for the experimental models and processes that are being utilized and has working knowledge of the patient-level associations that are being evaluated.

Qualifications / Essential Skills

MS with 7-8 years experience in cancer biology, cell and / or molecular biology or a related field, with a minimum of 3 years in a biotech/pharma setting.

1-2 years hands on experience with guiding/managing day-to-day activities of assistant/associate researchers within the lab

Ideally candidate will have developed lab techniques that address the mechanisms of therapeutic response and resistance utilizing in vitro , in vivo (and potentially ex vivo ) models

Deep and broad knowledge of molecular and cellular techniques including DNA/RNA/protein isolations from clinical specimens, generation of short-term cultures and organoids, secretion profiling, qPCR and other gene expression techniques, including exposure to WES/WTS methodology.

A keen ability to learn and adopt new techniques and implement new protocols highly desired.

Also experience in tumor/tissue banking processes and protocols would be beneficial

Prior experience as part of a multidisciplinary team in an academic or industry setting

Excellent written and oral presentation skills and flexibility and proactive approach to taking on a multi-functional role within a large cross-function team.

Level-headed, multi-tasker who embraces challenge

We follow the science and we'll continue to invest in translational medicine research, deepen our understanding of disease biology and uncover insights about predictive biomarkers with the ultimate goal of making precision medicine a reality for more patients.