Bristol-Myers Squibb Company

Genomics Research Scientist

Location
Hopewell, NJ, United States
Posted
Aug 09, 2019
Ref
R1515829
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Clinical Genetics and Genomics team is seeking an innovative and highly motivated scientist to join our world-class team. The selected scientist will be responsible for genomics biomarker assay development, optimization, validation and execution of biomarker analysis for BMS translational research and clinical programs. The scientist must have a strong background in genomics as well as experience with and understanding of immunology, immunooncology and related disciplines.

  • Assay design and development: Understand program biology requirements working with the biomarker and program leads and help develop the genomics biomarker strategy and execution plan working with the technology leads.
  • Design, develop, optimize genomics and genetics biomarker assays and develop and execute the validation of these assays for clinical trial assays.
  • Key assay profiles likely to include NGS or qPCR based gene expression systems, genotyping or variant analysis utilizing NGS or qPCR or other methodologies.
  • This is a lab based position with a significant opportunity to interface with program teams to understand program requirements and background, assay and analysis requirements, analysis timelines, analysis needs.
  • A significant part of time will be spent assisting development and analysis of validation data. A strong understanding of assay validation and fit for purpose assay validation requirements will be essential.
  • In case of outsourced studies, the incumbent will provide oversight of assay development and execution of sample analysis at the vendor.
  • Help to draft experimental plans, validation reports, work instructions, technology transfer documents, study summaries and SOPs.
  • Actively participate in internal/external collaboration, portfolio management groups and clinical study and biomarker execution teams.
  • Providing subject matter expertise for clinical and program teams as required.
  • Accurate record keeping of experiments and procedures
  • Observe technology developments and innovate on new methodology per team requirements.
  • Work closely with data analysis teams as well as sample management and clinical operation teams on programs.


Minimum Requirements:
  • Minimum educational requirement - Phd with work experience or Postdoc with Genomics fluency and hands on experience with application of genomics technologies.
  • PhD in relevant discipline with optional work experience or Masters with 5+ years experience in Pharma R&D, clinicalor diagnostic lab with assay development and validation experience.
  • Experience in genomics based studies applied to drug development, biomarker and diagnostic development.
  • Significant work experience in clinical assay development for gene expression profiling assets for example.
  • Understanding of fit for purpose genomics assay validation principles for clinical assays
  • Experience with genomics (NGS, qPCR, gene expression and variant analysis platforms) assay development, validation, troubleshooting, and reviewing of run QC data.
  • In-depth knowledge of different genomics platforms and technologies (for the clinic).
  • Familiarity with NGS and qPCR data analysis and QC to develop a strong interaction with the data analysis team.
  • Technical expertise with molecular technologies, including but not limited to: nucleic acid extraction, QA/QC, PCR, quantitative real-time PCR, digital PCR, NanoString,and other relevant methodologies.
  • Must have strong organizational and interpersonal skills with excellent leadership skills.
  • Must be self-motivated, with demonstrated ability to work independently and learn quickly.
  • Must be goal oriented and focused on completing work on time.
  • Thrive in a highly interactive, fast-paced and dynamic team environment.
  • Must be able to quickly adapt to changing priorities and work well in fast pace environment and under pressure.
  • Ability to mentor others on technical operating systems
  • Ability to independently review and understand project proposals/plans
  • Ability to work in a matrixed team in a high pressure environment.
  • Excellent communication skills with ability to serve as key contact for program teams.
  • Must have excellent organization and record keeping skills
  • Must be highly resourceful and work across matrix teams.


Preferred Qualifications:

• Previous industry experience is preferred.

• Previous experience working with genomics assays in a clinical laboratory setting is a plus

• Bioinformatics skills, experience with data interpretation and basic data analysis is a plus.

• Understanding of design of experiments, randomization of samples for clinical analysis.