Bristol Myers Squibb Company

Research Investigator / Senior Research Investigator, Membrane Protein

Redwood City, CA, United States
Aug 09, 2019
Required Education
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.


We are seeking a skilled and enthusiastic protein biochemist at a Research Investigator/Senior Research investigator level to join the Protein Engineering group. The candidate will be expected to lead a variety of efforts to design and generate membrane proteins, identify and implement novel methodologies to enhance membrane protein expression, purification, and functional characterization. The candidate would also be expected to work on a variety of protein engineering projects to optimize and generate differentiated antibody therapeutic leads.

Specific Responsibilities
  • Scientifically champion efforts to design and generate protein antigens with a focus on membrane proteins
  • Identify and implement methodologies to enhance membrane and soluble protein generation
  • Engineer variable and constant domains of antibodies to generate novel therapeutic leads
  • Elucidate mechanistic understanding of targets and work to progress targets through pipeline
  • Generate materials for therapeutic program immunizations and antibody screening
  • Interface with project leads, antibody generation and translational teams
  • Independently perform complex experiments with strong attention to detail and documentation.
  • Excellent written and oral skills are necessary

  • Ph.D. in Biochemistry, cell biology, structural Biology, or similar fields with more than 3 years of post Ph.D. experience
  • Extensive experience in generation and characterization of membrane proteins such as GPCRs
  • Expertise in in molecular biology, protein expression, purification, and functional characterization
  • Experience in display technologies (yeast, phage, mammalian systems)a plus
  • Familiarity with immunology and immune-oncology is desirable
  • Excellent time management and organizational skills
  • Ability to work in a multidisciplinary biologics discovery team

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.