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Lead, In Vivo Screening Biology, Research Investigator.

Employer
Bristol Myers Squibb Company
Location
Cambridge, MA, United States
Start date
Aug 9, 2019

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Job Details

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Research Investigator will join the Discovery Pharmacology and In Vivo Biology Group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The successful candidate will possess expertise in mouse tumor models and in vivo pooled CRISPR screens and leverage these skills to drive in vivo target identification efforts. The successful candidate's team will also plan, execute and analyze preclinical in vivo studies, e.g. PK/PD and efficacy, interrogating our immuno-oncology and resistance biology portfolio.

The qualified candidate is a highly motivated, creative, and collaborative individual that possesses the ability to work across a highly matrixed environment and communicate effectively with multidisciplinary teams and key stakeholders. You are expected to leverage your experience and skills to train and coach a team of research scientists. We value what you do and how you do it.

Position Description

The Research Investigator will join the Discovery Pharmacology and In Vivo Biology Group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The successful candidate will possess expertise in mouse tumor models and in vivo pooled CRISPR screens and leverage these skills to drive in vivo target identification efforts. The successful candidate's team will also plan, execute and analyze preclinical in vivo studies, e.g. PK/PD and efficacy, interrogating our immuno-oncology and resistance biology portfolio.

The qualified candidate is a highly motivated, creative, and collaborative individual that possesses the ability to work across a highly matrixed environment and communicate effectively with multidisciplinary teams and key stakeholders. You are expected to leverage your experience and skills to train and coach a team of research scientists. We value what you do and how you do it.

Job Responsibilities and requirements

A PhD degree and postdoctoral training in cancer biology, or a closely related field, or a minimum of 2 years industry experience is required.

Demonstrated expertise designing and conducting in vivo CRISPR screens to identify novel targets is required.

In collaboration with colleagues in Oncology Discovery New Target Biology, design and execute in vivo pooled forward genetic screens to identify and validate new targets that modulate immune function and/or tumor cell biology.

In collaboration with Oncology Discovery colleagues, design and plan in vivo studies (including PK/PD and efficacy studies) to interrogate novel therapeutics modulating targets relevant to immune function and/or tumor cell biology

Develop a team of in vivo research scientists; train and mentor colleague

Collaborate with the Vet Sciences to ensure compliance with BMS and external animal welfare regulations.

Develop new animal models and incorporate new technologies to enable the exploration of novel therapeutics.

Communication of work, plans and progress using written and verbal communication in small and group settings

Extensive experience designing and conducting GEM or syngeneic tumor models and xenograft tumor models to explore tumor biology and immune-oncology.

Expertise with CRISPR, cell culture and ex vivo sample analysis, e.g. qPCR, ELISA

Experience in the development and utilization of multi-color flow cytometry to interrogate treatment mediated changes to the microenvironment of syngeneic tumors is a plus

Demonstrated capability to train others in in vivo and in vitro techniques

Demonstrated ability to integrate knowledge from literature

Excellent oral and written communication skills

Excellent interpersonal skills and ability to work in a fast-paced and dynamic environment is essential.

The ability to manage a small laboratory group is expected, including providing growth and development opportunities for direct reports.

This position will have up to 4 direct reports

This position is located in Cambridge, MA. There will be less than 10% travel.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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Company info
Website
Phone
+1-800-332-2056
Location
430 E. 29th St
14th Floor
New York
New York
10016
United States

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