Senior Scientist II/III, Computational Biology

Redwood City, CA, US
Aug 09, 2019
Required Education
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.

AbbVie Biotherapeutics, a center of innovation in oncology R&D located in Redwood City, California, is seeking a computational biology/bioinformatics at scientist or senior scientist levels, to play an integral role in a multi-disciplinary team focused on solving large-scale scientific problems in the immuno oncology field.

The successful candidate will provide computational biology support to a team of highly skilled immune-oncology scientists and interact with peers across a highly collaborative and science-driven organization to create, investigate and characterize novel therapeutics. This will involve formulating and answering biological questions using complex datasets and the creation and assessment of novel computational solutions. You will work in a well-supported environment, with access to the tools, technologies and expertise necessary for success.

Key Responsibilities:

  • Analysis - Interrogate large scale -omics data from both pre-clinical models and clinical samples in support of new therapeutic discoveries for the treatment of cancer.
  • Build - through your own efforts or by working with software engineers develop world-class bioinformatics capabilities (genomic databases and analytics software/pipelines) to support a dynamic oncology pipeline.
  • Collaborative Design - you should find it inspiring to work with a wide variety of colleagues (e.g., biology, chemistry, business); understand their needs and then propose and build solutions
  • Presentation - use your strong computational and data visualization skills to bring together disparate data types in compelling visualization packages that provide end users with the ability to see both 'the landscape' and details leading to improved decision-making
  • Adaptability - given our diverse mission you should be able to move fluidly between different project responsibilities
  • Breadth - as a talented and motivated Biology Data Scientist you can contribute to a wide variety of missions related to enhancing drug discovery
  • Scientists are expected to work in research teams, to be member of the scientific community by publishing in top-tier conferences and journals, and collaborate with peer researchers and software engineers to develop solutions, necessary prototypes, and intellectual property in the form of disclosures and patent applications. Scientists are expected to contribute towards the research efforts of AbbVie and to develop research expertise to tackle the research challenges of interest.
  • In addition to the duties above, Senior Scientists are expected to have sufficient experience and accomplishments that qualify them to lead research projects and contribute to the broad research community of AbbVie

  • PhD with typically 4+ (Senior Scientist II) or 6+ (Senior Scientist III) years of experience in scientific area of discipline
  • Raises the bar and is never satisfied with the status quo
  • Several years of experience and demonstrated skills/accomplishments in an immune-oncology/oncology setting is highly desired
  • Expertise in computational biology/bioinformatics, genomic analysis, data and literature mining, disease and biological pathway and gene network/ systems biology analysis.
  • Strong data analytical skills, expertise in various bioinformatics software, databases, and programming packages including R, Shiny, Python or Perl.
  • Understand how to use and leverage containers for deploying standard pipelines (Docker, AWS Container, etc.)
  • Familiarity with running standard pipelines and generating QC reports on one or more of NGS based technologies (RNA-Seq, single cell RNA-Seq, DNA-Seq for Genome/Exome sequencing, ATAC-Seq), Proteomics technologies (Mass Spec based Proteomics), Methylation, Somatic Variant Calling and annotation, Targeted Mutational Profiling, Copy Number Variation, and standard microarray based technologies (Affymetrix, Illumina)
  • Good grasp of biochemistry, immunology, cancer biology and related subjects.
  • Strong communication skills with people from different academic backgrounds.
  • Experience with biomarker strategies for drug development in areas including -omics, immuno-oncology, is valued.
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the 'essence' and can change the course quickly where indicated
  • Creates a learning environment, open to suggestions and experimentation for improvement