Principal Scientist - Clinical Biomarkers & Diagnostics

South San Francisco, CA, US
Aug 09, 2019
Required Education
Bachelors Degree
Position Type
Full time
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing our Translational Science focus with modern molecular and cellular science and pathology laboratories, designed to discover and develop valuable biomarkers in support of clinical programs.

Amgen R&D Medical Sciences/Clinical Biomarkers & Diagnostics (CBD) is looking for a Principal Scientist dedicated to clinical biomarker development. This position will primarily support biomarker discovery and development for our hematologic cancer portfolio.

The successful candidate is expected to work cross-functionally within Amgen and interact closely with both the clinical and discovery research groups. In addition, the successful candidate will be expected to engage key opinion leaders and the external research community to develop and implement the biomarker strategy in support of our hematologic cancer pipeline.

As Amgen continues to develop and expand our oncology pipeline the successful candidate will be expected to be play a key role in the strategic leadership of our biomarker division, which will include managing a group of biomarker scientists working on multiple project teams.

The candidate will interface with oncology research, early and late stage clinical development, and IVD teams throughout the drug development process.

The candidate is expected to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community.

Basic Qualifications

Doctorate degree and 3 years Scientific experience


Master's degree and 6 years Scientific experience


Bachelor's degree and 8 years Scientific experience

Preferred Qualifications

Ph.D and 5+ years of industry experience in translational research

Experience managing junior scientists or research associates

Extensive experience in hematology/hematological cancer

Established track record of interrogating immune cell populations as they relate to the various forms of leukemia/lymphoma and Myeloma, as well as an in-depth understanding of immunologic pathways

Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers

Strong background in tumor biology and cancer genomics with practical experience in successful preclinical biomarker discovery/validation and implementing biomarker assays in a clinical trial setting

Familiarity with assay development and qualification

Demonstrated the ability to establish and execute external collaborations with both academic laboratories as well as CROs

Knowledge of technical and regulatory requirements for diagnostic development

Outstanding communication skills including both oral and written presentation

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:
  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.