R&D Specialist - In-Vivo Delivery of CRISPR Therapeutics

Location
Tarrytown, NY, United States
Posted
Aug 05, 2019
Ref
17185BR
Required Education
Bachelors Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

We are seeking a highly motivated R&D Specialist to join Regeneron's VelociGene group to support our program in developing CRISPR based therapeutics and other novel in vivo mouse delivery platforms. This individual is expected to develop, execute, and validate a broad array of in vivo based experimental delivery mechanisms of CRISPR reagents. The responsibilities for this position would include working with rodents (blood collection, animal handling, animal injections, necropsies) which will lead to validating phenotypic outcomes of CRISPR based gene modulation. In addition, the applicant should have solid understanding of molecular biology, cell biology, biochemistry, and genetics and be able to perform Westerns, ELISAs, and IHCs and have the skills to develop techniques for delivery of reagents in vivo. The candidate must be able to correctly document the results, analyze the data and communicate the results clearly and concisely. The candidate is expected to work independently and collaboratively in a dynamic team environment.

Requirements:
This position requires a Bachelor's with at least 3 years of experience and/or a Master's degree with at least 2 years of experience. Additional requirements include:
- Ability to design and perform in vivo experiments in various mouse models (2-3 years experience a must)
- Experience with rodents (handling, dosing, blood and urine collection, tissue harvesting etc.)

- Surgical techniques or primary cell isolation are a plus

- Ability to perform immunohistochemistry (IHC) and immunofluorescence on various tissues. Microscopy and FACs analysis.

- Molecular benchwork abilities: DNA/RNA prep, Taqman, PCR, ELISAs, Westerns.

- Maintain clear record of work in a laboratory notebook, updated in a timely and comprehensive manner.

- Present findings at group meetings, and format data for presentation to senior staff.

- Understanding the principles of molecular biology, genetics, and cell biology

- Strong computer skills and experience with MS Office and PRISM

Physical Positions:

This position will require the individual to pass a physical before beginning employment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.