Amgen

Director - Computational Biology

Employer
Amgen
Location
South San Francisco, CA, US
Posted
Jul 22, 2019
Ref
R-77726
Discipline
Science/R&D, Biology
Required Education
Bachelors Degree
Position Type
Full time
At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

The Clinical Biomarkers & Diagnostics department at Amgen is seeking a highly motivated Director of Computational Biology and will work out of our Thousand Oaks or South San Francisco research sites.

The Computational Biology group is responsible for biomarker data analysis for all Amgen's first-in-human studies in all therapeutic areas. In that capacity, we conduct the statistical analysis of clinical biomarker data to demonstrate the pharmacodynamic effects of our therapeutics and in the pursuit of biomarker discoveries that will aid in drug development and patient stratification.
The successful candidate is expected to work cross-functionally within Amgen and to interact closely with the clinical development groups.
The position will focus on leading a team to develop and execute a biomarker data analysis strategy that informs biochemical coverage, pharmacodynamics, mechanism of action, and patient stratification/selection in support of the progression of Amgen's pipeline candidates from late preclinical development through all stages of clinical development.
The role is also responsible for directing and approving experimental designs, the creation and implementation of data analysis plans, as well as interpreting and communicating results as written reports and verbally to cross-functional teams.
The core computational function of the group requires that we leverage and manipulate highly complex internal and external datasets, and we expect the candidate to have a deep understanding of cutting edge tools in statistics, machine learning and AI.
In addition, the group interfaces closely with assay laboratories and the In-vitro Diagnostics group in the development of biomarker assays, companion and complementary diagnostics. As such a deep knowledge of assay qualification and IVD development is an important aspect of the group and the role.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development Ways that you will display your leadership acumen in this role include:

Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans
Assisting staff with preparing for roles of growing responsibility and identifying new opportunities that expand their skills and align with their overall career objectives
Resolving critical gaps in the organization's internal capabilities and skillsets, including strategic external recruiting
Identifying diverse, qualified successors for key positions
Ensuring that direct reports who also lead people consistently demonstrate these same behaviors with their staff

Basic Qualifications:
Doctorate degree and 4 years of scientific experience
OR
Master's degree and 7 years of scientific experience
OR
Bachelor's degree and 9 years of scientific experience

Preferred Qualifications:
Advanced degree in Bioinformatics, Biostatistics, Computer Science, Genomics
Experience in analyzing clinical biomarker data
Knowledge and experience in clinical trial design
Experience in companion diagnostics development and knowledge of regulatory submission requirements of in vitro diagnostic devices in multiple markets
5+ years of experience in pharmaceutical industry
Hands-on experience in the fields of bioinformatics and genomics including working with various public and proprietary data repositories (e.g., TCGA, GTEx, dbGaP, Ensembl, UCSC genome browser, Array Studio), bioinformatics tools (e.g., BLAST, GATK, Cell Ranger, samtools, VEP), and statistical environments (e.g., R, S+, Matlab)
Experience with manipulation, interpretation, and innovative analysis (e.g. novel algorithm development) of large biological datasets, including single-cell sequencing data
Proficient in programming (e.g., Python, Java, C/C++) and working in a Unix/Linux environment; ability to develop customized bioinformatics tools
Experience integrating data from multiple sources and identifying critical process variables.
Experience establishing and reviewing complex plans for multiple projects or activities. This includes planning resource allocation and distribution and identifying contingency plans.

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.