Bristol-Myers Squibb Company

Research Scientist In-Vivo Pharmacology

Cambridge, MA, United States
Jul 22, 2019
Required Education
Bachelors Degree
Position Type
Full time
Job Description: In Vivo Pharmacology Research Scientist

The In Vivo Pharmacology Research Scientist will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA. The individual hired for this position will conduct experiments utilizing tumored mouse or rat models to aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities.

  • A B.S. with a minimum of 7 years, or an M.S. with a minimum of 5 years of leveraging in vivo pharmacology models to explore cancer biology and enable drug discovery is required.
  • Demonstrated experience independently running and analyzing data from in vivo xenograft or syngeneic tumor efficacy and PK/PD studies is required.
  • Required skills include: tumor model development, dosing (IV, IP, SC, I-TUMOR and PO routes), tumor measurements by caliper, blood collection and tissue/tumor collection at necropsy
  • Proficiency in cell culture is required.
  • Experience with ex vivo techniques such as qPCR, ELISA (MSD), or WB is highly desired.
  • Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
  • Ability to mentor junior scientists and colleagues on best practices in the laboratory would be highly valued.
  • Attention to detail with excellent organizational and record keeping skills is a requirement.

Responsibilities include:
  • Independently conduct and analyze xenograft and syngeneic in vivo efficacy and PK/PD studies
  • Mentor junior associates on best practices (in vivo and ex vivo)
  • Utilize ELISAs (MSD), qPCR, or WB to monitor biomarkers in harvested tissues
  • Accurately maintain proper scientific documentation of experiments and associated data in an electronic lab notebook.
  • Effectively communicate and present summaries of research results to team members.
  • This position is located in Cambridge, MA.